Implications of p53 protein upregulation in oral lichen planus: a systematic review and meta-analysis

• Published in: Medicina oral, patología oral y cirugía bucal patología oral y cirugía bucal, 2024-11, Vol.29 (6), p.e832-e842
• Main Authors: Keim-Del Pino, C, Ramos-García, P, Pimenta-Barros, L-A, González-Moles, M-Á
• Format: Article
• Language: English
• Subjects: Humans; Lichen Planus, Oral - metabolism; Lichen Planus, Oral - pathology; Mouth Neoplasms - metabolism; Mouth Neoplasms - pathology; Review; Tumor Suppressor Protein p53 - analysis; Tumor Suppressor Protein p53 - metabolism; Up-Regulation
• ISSN: 1698-6946; 1698-4447; 1698-6946
• DOI: 10.4317/medoral.26808

This systematic review and meta-analysis qualitatively and quantitatively analyzes the current evidence on the implications of p53 upregulation in oral lichen planus (OLP) assessed by immunohistochemical techniques, in order to identify molecular mechanisms involved in the behavior of OLP as an oral potentially malignant disorder. We searched MEDLINE/PubMed, Embase, Web of Science and Scopus for studies published before February-2024. We critically assessed the methodological quality of primary-level studies and performed meta-analyses. Twenty-four individual studies met the inclusion criteria, comprising 721 OLP samples, in which the expression of p53 was analyzed through immunohistochemistry. Most OLP displayed p53 protein upregulation (pooled proportion [PP]= 66.76%, 95%CI=54.84-77.76). Regarding the magnitude of association analysis, oral squamous cell carcinoma (OSCC) cases showed a significantly higher frequency according to p53 expression in comparison to OLP (OR=2.79, 95%CI=1.84-4.24; p