Enhancement of rat brain catecholamine synthesis by administration of small doses of tyrosine and evidence for substrate inhibition of tyrosine hydroxylase activity by large doses of the amino acid

Rat brain catecholamine synthesis is enhanced by small doses of tyrosine, but not by doses of 50mg/kg body wt. and above. It is suggested that these latter doses overcome the above enhancement by causing a substrate inhibition of tyrosine hydroxylase activity.

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Bibliographic Details
Published in:Biochemical journal 1982-07, Vol.206 (1), p.165-168
Main Authors: Badawy, A A, Williams, D L
Format: Article
Language:English
Subjects:
Animals
Brain - drug effects
Brain - enzymology
Brain - metabolism
Catecholamines - biosynthesis
Dose-Response Relationship, Drug
In Vitro Techniques
Male
Metabolism, Regulation and Control Processes
Rats
Rats, Inbred Strains
Tyrosine - blood
Tyrosine - pharmacology
Tyrosine 3-Monooxygenase - antagonists & inhibitors
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Description
Summary:Rat brain catecholamine synthesis is enhanced by small doses of tyrosine, but not by doses of 50mg/kg body wt. and above. It is suggested that these latter doses overcome the above enhancement by causing a substrate inhibition of tyrosine hydroxylase activity.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj2060165