Loading…

Conversion surgery for esophageal and esophagogastric junction cancer

As a result of the recent advances in first-line treatment including chemotherapy, radiation therapy, targeted therapy, and immune checkpoint inhibitor immunotherapy (ICI) for locally advanced/metastatic initially unresectable esophageal and esophagogastric junction cancer, surgery aiming at cure af...

Full description

Saved in:
Bibliographic Details
Published in:International journal of clinical oncology 2024-12, Vol.29 (12), p.1777-1784
Main Authors: Shoji, Yoshiaki, Kanamori, Kohei, Koyanagi, Kazuo, Otsuka, Tetsuya, Nakashima, Rie, Tajima, Kohei, Ogimi, Mika, Ninomiya, Yamato, Yamamoto, Miho, Kazuno, Akihito, Nishi, Takayuki, Mori, Masaki
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:As a result of the recent advances in first-line treatment including chemotherapy, radiation therapy, targeted therapy, and immune checkpoint inhibitor immunotherapy (ICI) for locally advanced/metastatic initially unresectable esophageal and esophagogastric junction cancer, surgery aiming at cure after initial treatment, so-called “conversion surgery” has become more common in this field. Several studies have indicated encouraging survival outcomes for patients after conversion surgery with R0 resection. However, various issues, such the utility and the safety of conversion surgery remain unclear. In this review, we will focus on the surgical treatment for initially unresectable esophageal and esophagogastric junction cancer after first- or later- line treatment and review recent evidence regarding the safety and the efficacy of conversion surgery. Multidisciplinary treatment including surgery may serve as a novel treatment strategy for esophageal and esophagogastric junction cancer, thus provide a curative treatment option and potentially contribute to better prognosis for initially untreatable diseases.
ISSN:1341-9625
1437-7772
1437-7772
DOI:10.1007/s10147-024-02639-4