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The renin-angiotensin-aldosterone-system in sepsis and its clinical modulation with exogenous angiotensin II

Dysregulation of the renin-angiotensin-aldosterone-system (RAAS) in sepsis is a complex and early phenomenon with a likely significant contribution to organ failure and patient outcomes. A better understanding of the pathophysiology and intricacies of the RAAS in septic shock has led to the use of e...

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Published in:Critical care (London, England) England), 2024-11, Vol.28 (1), p.389, Article 389
Main Authors: Legrand, Matthieu, Khanna, Ashish K, Ostermann, Marlies, Kotani, Yuki, Ferrer, Ricard, Girardis, Massimo, Leone, Marc, DePascale, Gennaro, Pickkers, Peter, Tissieres, Pierre, Annoni, Filippo, Kotfis, Katarzyna, Landoni, Giovanni, Zarbock, Alexander, Wieruszewski, Patrick M, De Backer, Daniel, Vincent, Jean-Louis, Bellomo, Rinaldo
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Language:English
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Summary:Dysregulation of the renin-angiotensin-aldosterone-system (RAAS) in sepsis is a complex and early phenomenon with a likely significant contribution to organ failure and patient outcomes. A better understanding of the pathophysiology and intricacies of the RAAS in septic shock has led to the use of exogenous angiotensin II as a new therapeutic agent. In this review, we report a multinational and multi-disciplinary expert panel discussion on the role and implications of RAAS modulation in sepsis and the use of exogenous angiotensin II. The panel proposed guidance regarding patient selection and treatment options with exogenous angiotensin II which should trigger further research.
ISSN:1364-8535
1466-609X
1466-609X
1364-8535
DOI:10.1186/s13054-024-05123-7