Noncoding RNA

Regulatory RNAs, present in many bacterial genomes and particularly in pathogenic bacteria such as , control the expression of genes encoding virulence factors or metabolic proteins. They are extremely diverse and include noncoding RNAs (sRNA), antisense RNAs, and some 5' or 3' untranslate...

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Bibliographic Details
Published in:Microbiology spectrum 2019-03, Vol.7 (2)
Main Authors: Desgranges, E, Marzi, S, Moreau, K, Romby, P, Caldelari, I
Format: Article
Language:English
Subjects:
Animals
Bacterial Genetics, Cell Biology, Physiology
Biochemistry, Molecular Biology
Gene Expression Regulation, Bacterial
Genome, Bacterial
Humans
Life Sciences
Molecular biology
RNA, Bacterial
RNA, Bacterial - genetics
RNA, Bacterial - metabolism
RNA, Small Untranslated
RNA, Small Untranslated - metabolism
Staphylococcal Infections - microbiology
Staphylococcus aureus
Staphylococcus aureus - genetics
Staphylococcus aureus - metabolism
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Description
Summary:Regulatory RNAs, present in many bacterial genomes and particularly in pathogenic bacteria such as , control the expression of genes encoding virulence factors or metabolic proteins. They are extremely diverse and include noncoding RNAs (sRNA), antisense RNAs, and some 5' or 3' untranslated regions of messenger RNAs that act as sensors for metabolites, tRNAs, or environmental conditions (e.g., temperature, pH). In this review we focus on specific examples of sRNAs of that illustrate how numerous sRNAs and associated proteins are embedded in complex networks of regulation. In addition, we discuss the CRISPR-Cas systems defined as an RNA-interference-like mechanism, which also exist in staphylococcal strains.
ISSN:2165-0497
2165-0497
DOI:10.1128/microbiolspec.GPP3-0038-2018