The Relation of Insulin Resistance With Free Androgen Index and Endothelial Dysfunction Marker YKL-40 and Its Effect on Male Infertility: A Prospective Study

In this study, the effects of insulin resistance and the role of the endothelial dysfunction marker YKL-40 in male infertility were investigated. This study was conducted with male patients who underwent fertility investigations in the in vitro fertilization (IVF) unit of a tertiary center. Semen sa...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-10, Vol.16 (10), p.e72481
Main Authors: Yilmaz, Muserref Banu, Keyif, Betül
Format: Article
Language:English
Subjects:
Androgens
Body mass index
Chitinase
Cholesterol
Correlation analysis
Diabetes
Fertility
Glucose
Hormones
Infertility
Insulin resistance
Laboratories
Lipids
Lipoproteins
Metabolic syndrome
Motility
Obstetrics/Gynecology
Other
Proteins
Sperm
Testosterone
Thyroid gland
Womens health
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Summary:In this study, the effects of insulin resistance and the role of the endothelial dysfunction marker YKL-40 in male infertility were investigated. This study was conducted with male patients who underwent fertility investigations in the in vitro fertilization (IVF) unit of a tertiary center. Semen samples were evaluated after two to five days of sexual abstinence. The hormonal and lipid profiles, fasting glucose and insulin levels, and YKL-40 values of the patients were assessed. The Homeostatic Model Assessment (HOMA) index was calculated, and those with a score of 2.5 and above were considered insulin resistant (IR). In total, 75 patients, 34 with IR and 41 without IR, were included. The groups had similar ages, heights, weights, and BMIs. Additionally, the semen parameters were similar between the groups. The median fasting glucose and insulin levels were significantly greater in the insulin-resistant group (p=0.008 and p
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.72481