Unlocking the Future: New Biologic Therapies for Rheumatoid Arthritis

Rheumatoid arthritis (RA) is a chronic autoimmune disorder that leads to joint destruction and functional disability. Traditional treatments, including disease-modifying antirheumatic drugs (DMARDs), often fail, leaving many patients without remission. The advent of biologic therapies that target sp...

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Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-10, Vol.16 (10), p.e72486
Main Authors: Patil, Sarika J, Thorat, Vandana M, Koparde, Akshada A, Bhinge, Somnath D, Chavan, Dhanashri D, Bhosale, Rohit R
Format: Article
Language:English
Subjects:
Autoimmune diseases
Biological products
Cartilage
Chronic illnesses
Cytokines
Disease
Drugs
Fibroblasts
Health risk assessment
Hyperplasia
Immune system
Inflammation
Medical research
Pain Management
Pathogenesis
Pathophysiology
Patients
Pharmaceutical industry
Pharmacology
Quality of life
Remission (Medicine)
Rheumatoid arthritis
Rheumatology
Tumor necrosis factor-TNF
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Summary:Rheumatoid arthritis (RA) is a chronic autoimmune disorder that leads to joint destruction and functional disability. Traditional treatments, including disease-modifying antirheumatic drugs (DMARDs), often fail, leaving many patients without remission. The advent of biologic therapies that target specific immune system components (e.g., cytokines, T cells) has transformed RA treatment by offering new management options. These biologics (e.g., TNF inhibitors, interleukin blockers) are highly effective in controlling disease activity and preventing joint destruction. However, their use comes with safety concerns, particularly regarding immunosuppression and infection risks. Although still experimental, studies predict that future research will focus on enhancing the clinical response and safety of these agents through personalized approaches or novel mechanisms of action.
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.72486