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Relationship Between Loss of Y Chromosome and Urologic Cancers: New Future Perspectives
The Y chromosome (ChrY) is essential for male sex determination and spermatogenesis. However, recent studies have revealed its broader role in various physiological processes and disease susceptibility, including cancer. A comprehensive literature review was conducted using databases like MEDLINE, S...
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| Published in: | Cancers 2024-11, Vol.16 (22), p.3766 |
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| creator | Russo, Pierluigi Bizzarri, Francesco Pio Filomena, Giovanni Battista Marino, Filippo Iacovelli, Roberto Ciccarese, Chiara Boccuto, Luigi Ragonese, Mauro Gavi, Filippo Rossi, Francesco Savoia, Cosimo Suraci, Paolo Pietro Falabella, Roberto Pandolfo, Savio Domenico Napolitano, Luigi Leoni, Chiara Trevisan, Valentina Palermo, Giuseppe Racioppi, Marco Sacco, Emilio Muselaers, Stijn Foschi, Nazario |
| description | The Y chromosome (ChrY) is essential for male sex determination and spermatogenesis. However, recent studies have revealed its broader role in various physiological processes and disease susceptibility, including cancer.
A comprehensive literature review was conducted using databases like MEDLINE, Scopus, Web of Science, and Google Scholar. The review included clinical and preclinical studies in animals and humans focusing on the role of LoY in urological tumors. Data on the frequency of LoY, its clinical implications, and underlying mechanisms were extracted and analyzed.
The evidence suggests that LoY is associated with an increased risk of urologic neoplasms, potentially serving as an early marker of genomic instability. Studies reveal that LoY in urologic cancers correlates with worse survival outcomes and may contribute to tumor progression. LoY may interfere with chromatin structure and epigenetic regulation, suggesting its role as a contributor to early tumorigenesis.
: LoY appears to be a structural aberration with unique biological and clinical relevance in urologic cancers, possibly serving as a biomarker for genomic instability. Further research is necessary to identify specific Y-linked genes affected by LoY, potentially informing targeted therapies and early diagnostic strategies for these cancers. |
| doi_str_mv | 10.3390/cancers16223766 |
| format | article |
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A comprehensive literature review was conducted using databases like MEDLINE, Scopus, Web of Science, and Google Scholar. The review included clinical and preclinical studies in animals and humans focusing on the role of LoY in urological tumors. Data on the frequency of LoY, its clinical implications, and underlying mechanisms were extracted and analyzed.
The evidence suggests that LoY is associated with an increased risk of urologic neoplasms, potentially serving as an early marker of genomic instability. Studies reveal that LoY in urologic cancers correlates with worse survival outcomes and may contribute to tumor progression. LoY may interfere with chromatin structure and epigenetic regulation, suggesting its role as a contributor to early tumorigenesis.
: LoY appears to be a structural aberration with unique biological and clinical relevance in urologic cancers, possibly serving as a biomarker for genomic instability. Further research is necessary to identify specific Y-linked genes affected by LoY, potentially informing targeted therapies and early diagnostic strategies for these cancers.</description><identifier>ISSN: 2072-6694</identifier><identifier>EISSN: 2072-6694</identifier><identifier>DOI: 10.3390/cancers16223766</identifier><identifier>PMID: 39594721</identifier><language>eng</language><publisher>Switzerland: MDPI AG</publisher><subject>Age ; Angiogenesis ; Bladder cancer ; Cancer ; Carcinogens ; Care and treatment ; Disease ; Epigenetics ; Females ; Gene expression ; Genetic aspects ; Genomes ; Genomic instability ; Immune response ; Kidney cancer ; Males ; Medical prognosis ; Metastasis ; Mutation ; Prognosis ; Review ; Sex determination ; Tumors ; Y chromosomes</subject><ispartof>Cancers, 2024-11, Vol.16 (22), p.3766</ispartof><rights>COPYRIGHT 2024 MDPI AG</rights><rights>2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2024 by the authors. 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c373t-6628b458a84f60e78d5948572f7e0ee825d5762bcc3ed674444ab1e766f794a63</cites><orcidid>0009-0005-8884-6573 ; 0000-0002-4089-637X ; 0009-0003-5141-7527 ; 0000-0002-7789-9486 ; 0000-0002-2908-6907 ; 0000-0002-1919-8729 ; 0000-0003-2036-0356 ; 0000-0003-2017-4270 ; 0000-0001-9994-4316 ; 0000-0003-4640-8354 ; 0000-0003-2119-9023 ; 0000-0001-9129-8479 ; 0000-0001-9621-3059 ; 0000-0002-1750-2117 ; 0000-0002-9566-4971 ; 0000-0003-0464-0788 ; 0000-0002-3861-3545</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3132950461/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3132950461?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25752,27923,27924,37011,37012,44589,53790,53792,74897</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39594721$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Russo, Pierluigi</creatorcontrib><creatorcontrib>Bizzarri, Francesco Pio</creatorcontrib><creatorcontrib>Filomena, Giovanni Battista</creatorcontrib><creatorcontrib>Marino, Filippo</creatorcontrib><creatorcontrib>Iacovelli, Roberto</creatorcontrib><creatorcontrib>Ciccarese, Chiara</creatorcontrib><creatorcontrib>Boccuto, Luigi</creatorcontrib><creatorcontrib>Ragonese, Mauro</creatorcontrib><creatorcontrib>Gavi, Filippo</creatorcontrib><creatorcontrib>Rossi, Francesco</creatorcontrib><creatorcontrib>Savoia, Cosimo</creatorcontrib><creatorcontrib>Suraci, Paolo Pietro</creatorcontrib><creatorcontrib>Falabella, Roberto</creatorcontrib><creatorcontrib>Pandolfo, Savio Domenico</creatorcontrib><creatorcontrib>Napolitano, Luigi</creatorcontrib><creatorcontrib>Leoni, Chiara</creatorcontrib><creatorcontrib>Trevisan, Valentina</creatorcontrib><creatorcontrib>Palermo, Giuseppe</creatorcontrib><creatorcontrib>Racioppi, Marco</creatorcontrib><creatorcontrib>Sacco, Emilio</creatorcontrib><creatorcontrib>Muselaers, Stijn</creatorcontrib><creatorcontrib>Foschi, Nazario</creatorcontrib><title>Relationship Between Loss of Y Chromosome and Urologic Cancers: New Future Perspectives</title><title>Cancers</title><addtitle>Cancers (Basel)</addtitle><description>The Y chromosome (ChrY) is essential for male sex determination and spermatogenesis. However, recent studies have revealed its broader role in various physiological processes and disease susceptibility, including cancer.
A comprehensive literature review was conducted using databases like MEDLINE, Scopus, Web of Science, and Google Scholar. The review included clinical and preclinical studies in animals and humans focusing on the role of LoY in urological tumors. Data on the frequency of LoY, its clinical implications, and underlying mechanisms were extracted and analyzed.
The evidence suggests that LoY is associated with an increased risk of urologic neoplasms, potentially serving as an early marker of genomic instability. Studies reveal that LoY in urologic cancers correlates with worse survival outcomes and may contribute to tumor progression. LoY may interfere with chromatin structure and epigenetic regulation, suggesting its role as a contributor to early tumorigenesis.
: LoY appears to be a structural aberration with unique biological and clinical relevance in urologic cancers, possibly serving as a biomarker for genomic instability. Further research is necessary to identify specific Y-linked genes affected by LoY, potentially informing targeted therapies and early diagnostic strategies for these cancers.</description><subject>Age</subject><subject>Angiogenesis</subject><subject>Bladder cancer</subject><subject>Cancer</subject><subject>Carcinogens</subject><subject>Care and treatment</subject><subject>Disease</subject><subject>Epigenetics</subject><subject>Females</subject><subject>Gene expression</subject><subject>Genetic aspects</subject><subject>Genomes</subject><subject>Genomic instability</subject><subject>Immune response</subject><subject>Kidney cancer</subject><subject>Males</subject><subject>Medical prognosis</subject><subject>Metastasis</subject><subject>Mutation</subject><subject>Prognosis</subject><subject>Review</subject><subject>Sex determination</subject><subject>Tumors</subject><subject>Y 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However, recent studies have revealed its broader role in various physiological processes and disease susceptibility, including cancer.
A comprehensive literature review was conducted using databases like MEDLINE, Scopus, Web of Science, and Google Scholar. The review included clinical and preclinical studies in animals and humans focusing on the role of LoY in urological tumors. Data on the frequency of LoY, its clinical implications, and underlying mechanisms were extracted and analyzed.
The evidence suggests that LoY is associated with an increased risk of urologic neoplasms, potentially serving as an early marker of genomic instability. Studies reveal that LoY in urologic cancers correlates with worse survival outcomes and may contribute to tumor progression. LoY may interfere with chromatin structure and epigenetic regulation, suggesting its role as a contributor to early tumorigenesis.
: LoY appears to be a structural aberration with unique biological and clinical relevance in urologic cancers, possibly serving as a biomarker for genomic instability. Further research is necessary to identify specific Y-linked genes affected by LoY, potentially informing targeted therapies and early diagnostic strategies for these cancers.</abstract><cop>Switzerland</cop><pub>MDPI AG</pub><pmid>39594721</pmid><doi>10.3390/cancers16223766</doi><orcidid>https://orcid.org/0009-0005-8884-6573</orcidid><orcidid>https://orcid.org/0000-0002-4089-637X</orcidid><orcidid>https://orcid.org/0009-0003-5141-7527</orcidid><orcidid>https://orcid.org/0000-0002-7789-9486</orcidid><orcidid>https://orcid.org/0000-0002-2908-6907</orcidid><orcidid>https://orcid.org/0000-0002-1919-8729</orcidid><orcidid>https://orcid.org/0000-0003-2036-0356</orcidid><orcidid>https://orcid.org/0000-0003-2017-4270</orcidid><orcidid>https://orcid.org/0000-0001-9994-4316</orcidid><orcidid>https://orcid.org/0000-0003-4640-8354</orcidid><orcidid>https://orcid.org/0000-0003-2119-9023</orcidid><orcidid>https://orcid.org/0000-0001-9129-8479</orcidid><orcidid>https://orcid.org/0000-0001-9621-3059</orcidid><orcidid>https://orcid.org/0000-0002-1750-2117</orcidid><orcidid>https://orcid.org/0000-0002-9566-4971</orcidid><orcidid>https://orcid.org/0000-0003-0464-0788</orcidid><orcidid>https://orcid.org/0000-0002-3861-3545</orcidid><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 2072-6694 |
| ispartof | Cancers, 2024-11, Vol.16 (22), p.3766 |
| issn | 2072-6694 2072-6694 |
| language | eng |
| recordid | cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11593089 |
| source | Open Access: PubMed Central; Publicly Available Content (ProQuest) |
| subjects | Age Angiogenesis Bladder cancer Cancer Carcinogens Care and treatment Disease Epigenetics Females Gene expression Genetic aspects Genomes Genomic instability Immune response Kidney cancer Males Medical prognosis Metastasis Mutation Prognosis Review Sex determination Tumors Y chromosomes |
| title | Relationship Between Loss of Y Chromosome and Urologic Cancers: New Future Perspectives |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-10T19%3A20%3A01IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Relationship%20Between%20Loss%20of%20Y%20Chromosome%20and%20Urologic%20Cancers:%20New%20Future%20Perspectives&rft.jtitle=Cancers&rft.au=Russo,%20Pierluigi&rft.date=2024-11-08&rft.volume=16&rft.issue=22&rft.spage=3766&rft.pages=3766-&rft.issn=2072-6694&rft.eissn=2072-6694&rft_id=info:doi/10.3390/cancers16223766&rft_dat=%3Cgale_pubme%3EA818105886%3C/gale_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c373t-6628b458a84f60e78d5948572f7e0ee825d5762bcc3ed674444ab1e766f794a63%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3132950461&rft_id=info:pmid/39594721&rft_galeid=A818105886&rfr_iscdi=true |