Multisystem Inflammatory Syndrome of Adults (MIS-A) as Delayed Severe Presentation of SARS-CoV-2 Infection: A Description of Two Cases

SARS-CoV-2 infection can lead to a potentially life-threatening condition known as SARS-CoV-2-associated multisystem inflammatory syndrome in children (MIS-C), which differs from the severe lung disease and thrombotic complications commonly seen in adults. Recently, similar cases have been identifie...

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Bibliographic Details
Published in:Journal of clinical medicine 2024-11, Vol.13 (22), p.6632
Main Authors: Raffeiner, Bernd, Rojatti, Marco, Tröbinger, Christian, Nailescu, Adriana Manuela, Pagani, Leonardo
Format: Article
Language:English
Subjects:
Adults
Antibodies
Biopsy
Blood tests
Cardiac arrhythmia
Case Report
COVID-19
Cytokine storm
Edema
Heart
Hypotension
Immunoglobulins
Immunology
Infection
Infections
Inflammation
Liver
Medical imaging
Mortality
Pandemics
Patients
Serology
Severe acute respiratory syndrome coronavirus 2
Skin
Thrombocytopenia
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Summary:SARS-CoV-2 infection can lead to a potentially life-threatening condition known as SARS-CoV-2-associated multisystem inflammatory syndrome in children (MIS-C), which differs from the severe lung disease and thrombotic complications commonly seen in adults. Recently, similar cases have been identified in adults, characterized by a clinical multisystem inflammatory syndrome referred to as MIS-A, which can emerge as a late and severe complication of SARS-CoV-2 infection. We report two cases of MIS-A that were recently admitted to our hospital. Both patients developed a severe multisystem inflammatory syndrome despite experiencing only mild SARS-CoV-2 infection. Key clinical features in both cases included significant systemic inflammation, prominent cardiac involvement, and thrombocytopenia. Prior SARS-CoV-2 infection was confirmed through serological testing. Treatment protocols for MIS-C, including steroids and immunoglobulins, proved effective for both patients. Clinicians should remain vigilant for MIS-A in the context of ongoing SARS-CoV-2 infection worldwide. This infection, even when presenting with mild or no symptoms, can progress to a life-threatening hyperinflammatory syndrome with cardiac implications if not promptly recognized and treated.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13226632