Drug Repurposing for Cancer Treatment: A Comprehensive Review

Cancer ranks among the primary contributors to global mortality. In 2022, the global incidence of new cancer cases reached about 20 million, while the number of cancer-related fatalities reached 9.7 million. In Saudi Arabia, there were 13,399 deaths caused by cancer and 28,113 newly diagnosed cases...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-11, Vol.25 (22), p.12441
Main Authors: Al Khzem, Abdulaziz H, Gomaa, Mohamed S, Alturki, Mansour S, Tawfeeq, Nada, Sarafroz, Mohammad, Alonaizi, Shareefa M, Al Faran, Alhassan, Alrumaihi, Laela Ahmed, Alansari, Fatimah Ahmed, Alghamdi, Abdullah Abbas
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - therapeutic use
Cancer therapies
Development and progression
Drug discovery
Drug Discovery - methods
Drug Repositioning - methods
Drug therapy
Health aspects
Humans
Mortality
Mutation
Neoplasms - drug therapy
Review
Saudi Arabia
Telmisartan
Thyroid cancer
Type 2 diabetes
Valsartan
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Summary:Cancer ranks among the primary contributors to global mortality. In 2022, the global incidence of new cancer cases reached about 20 million, while the number of cancer-related fatalities reached 9.7 million. In Saudi Arabia, there were 13,399 deaths caused by cancer and 28,113 newly diagnosed cases of cancer. Drug repurposing is a drug discovery strategy that has gained special attention and implementation to enhance the process of drug development due to its time- and money-saving effect. It involves repositioning existing medications to new clinical applications. Cancer treatment is a therapeutic area where drug repurposing has shown the most prominent impact. This review presents a compilation of medications that have been repurposed for the treatment of various types of cancers. It describes the initial therapeutic and pharmacological classes of the repurposed drugs and their new applications and mechanisms of action in cancer treatment. The review reports on drugs from various pharmacological classes that have been successfully repurposed for cancer treatment, including approved ones and those in clinical trials and preclinical development. It stratifies drugs based on their anticancer repurpose as multi-type, type-specific, and mechanism-directed, and according to their pharmacological classes. The review also reflects on the future potential that drug repurposing has in the clinical development of novel anticancer therapies.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms252212441