Formulation, E-Beam Crosslinking, and Comprehensive Characterisation of Lavender Oil-Enriched Hydrogels

This study focused on the formulation, electron beam (e-beam) crosslinking, and characterisation of hydrogels enriched with lavender oil (LO) to enhance their structural and functional properties for biomedical applications. Stable hydrogels were synthesised using water-soluble polymers and suitable...

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Bibliographic Details
Published in:Polymers 2024-11, Vol.16 (22), p.3150
Main Authors: Demeter, Maria, Călina, Ion, Scărișoreanu, Anca, Nemțanu, Monica R, Brașoveanu, Mirela, Micutz, Marin, Dumitru, Marius
Format: Article
Language:English
Subjects:
Analysis
Antimicrobial agents
Biocompatibility
Biological effects
Biological properties
Biomedical engineering
Biomedical materials
Cellulose
Chemical synthesis
Crosslinked polymers
Degradation
Drug delivery systems
Drug dosages
Drugs
Electron beams
Electrons
Enrichment
Hydrogels
Isopropanol
Lavender oil
Modulus of elasticity
Polyethylene
Radiation
Radiation crosslinking
Radiation dosage
Ratios
Shear stress
Structural analysis
Surface active agents
Surfactants
Swelling
Temperature
Vehicles
Viscosity
Water soluble polymers
Wound healing
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Summary:This study focused on the formulation, electron beam (e-beam) crosslinking, and characterisation of hydrogels enriched with lavender oil (LO) to enhance their structural and functional properties for biomedical applications. Stable hydrogels were synthesised using water-soluble polymers and suitable ratios of Tween 80 and Isopropyl alcohol (IPA) as surfactant and co-surfactant, respectively, via e-beam irradiation at doses up to 70 kGy. The most effective crosslinking was achieved with a radiation dose of 30 kGy, depending on the concentrations of surfactants and LO. LO-enriched hydrogels exhibited enhanced superabsorbent swelling (7700% to 18,000%) and faster equilibrium rates than the control hydrogel. Structural analysis revealed a flexible spongiform porous architecture with larger mesh sizes (156 nm to 246 nm) and adequate elastic moduli (130 to 308 Pa). Degradation tests aligned with swelling data, demonstrating a degradation rate of 12% after 35 days, indicating an appropriate balance of stability and degradation. These findings suggest that e-beam technology, in conjunction with LO and surfactant addition, can effectively tailor hydrogel properties for biomedical applications, making them promising candidates for further research in wound care, drug delivery systems, and other biological applications.
ISSN:2073-4360
2073-4360
DOI:10.3390/polym16223150