PREDBALB/c: a system for the prediction of peptide binding to H2d molecules, a haplotype of the BALB/c mouse

PREDBALB/c is a computational system that predicts peptides binding to the major histocompatibility complex-2 (H2d) of the BALB/c mouse, an important laboratory model organism. The predictions include the complete set of H2d class I (H2-Kd, H2-Ld and H2-Dd) and class II (I-Ed and I-Ad) molecules. Th...

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Bibliographic Details
Published in:Nucleic acids research 2005-07, Vol.33 (suppl-2), p.W180-W183
Main Authors: Zhang, Guang Lan, Srinivasan, Kellathur N., Veeramani, Anitha, August, J. Thomas, Brusic, Vladimir
Format: Article
Language:English
Subjects:
Animals
Computational Biology - methods
Epitopes, T-Lymphocyte - chemistry
Epitopes, T-Lymphocyte - metabolism
H-2 Antigens - genetics
H-2 Antigens - metabolism
Haplotypes
Internet
Mice
Mice, Inbred BALB C - genetics
Mice, Inbred BALB C - immunology
Peptides - chemistry
Peptides - immunology
Peptides - metabolism
Sequence Analysis, Protein
Software
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Summary:PREDBALB/c is a computational system that predicts peptides binding to the major histocompatibility complex-2 (H2d) of the BALB/c mouse, an important laboratory model organism. The predictions include the complete set of H2d class I (H2-Kd, H2-Ld and H2-Dd) and class II (I-Ed and I-Ad) molecules. The prediction system utilizes quantitative matrices, which were rigorously validated using experimentally determined binders and non-binders and also by in vivo studies using viral proteins. The prediction performance of PREDBALB/c is of very high accuracy. To our knowledge, this is the first online server for the prediction of peptides binding to a complete set of major histocompatibility complex molecules in a model organism (H2d haplotype). PREDBALB/c is available at http://antigen.i2r.a-star.edu.sg/predBalbc/.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gki479