GBA server: EST-based digital gene expression profiling

Expressed Sequence Tag-based gene expression profiling can be used to discover functionally associated genes on a large scale. Currently available web servers and tools focus on finding differentially expressed genes in different samples or tissues rather than finding co-expressed genes. To fill thi...

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Bibliographic Details
Published in:Nucleic acids research 2005-07, Vol.33 (suppl-2), p.W673-W676
Main Authors: Wu, Xin, Walker, Michael G., Luo, Jingchu, Wei, Liping
Format: Article
Language:English
Subjects:
Algorithms
Animals
Databases, Genetic
Expressed Sequence Tags
Gene Expression Profiling - methods
Humans
Internet
Mice
Rats
Sequence Analysis, DNA
Software
Systems Integration
User-Computer Interface
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Summary:Expressed Sequence Tag-based gene expression profiling can be used to discover functionally associated genes on a large scale. Currently available web servers and tools focus on finding differentially expressed genes in different samples or tissues rather than finding co-expressed genes. To fill this gap, we have developed a web server that implements the GBA (Guilt-by-Association) co-expression algorithm, which has been successfully used in finding disease-related genes. We have also annotated UniGene clusters with links to several important databases such as GO, KEGG, OMIM, Gene, IPI and HomoloGene. The GBA server can be accessed and downloaded at http://gba.cbi.pku.edu.cn.
ISSN:0305-1048
1362-4962
DOI:10.1093/nar/gki480