Dialkyl Carbamoyl Chloride (DACC)-Impregnated Dressings for the Prevention of Surgical Site Infections: Experience From a Multi-disciplinary Study in India

Background Surgical site infections (SSIs) represent a significant burden in healthcare, commonly occurring after surgical procedures and leading to prolonged recovery times and increased healthcare costs. Traditional antimicrobial dressings pose risks such as antimicrobial resistance. This study ai...

Full description

Saved in:
Bibliographic Details
Published in:Curēus (Palo Alto, CA) CA), 2024-10, Vol.16 (10), p.e72654
Main Authors: Mulpur, Praharsha, Jayakumar, Tarun, Sancheti, Parag K, Shankar, Navaladi, Hippalgaonkar, Kushal, Reddy, A V Gurava
Format: Article
Language:English
Subjects:
Antibiotics
Antimicrobial agents
Caregivers
Demographics
Diabetes
Disease prevention
Drug resistance
Gastroenterology
Gastrointestinal surgery
Healthcare Technology
Hospitals
Length of stay
Mortality
Nosocomial infections
Observational studies
Orthopedics
Patient satisfaction
Skin diseases
Surgical site infections
Wound healing
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Surgical site infections (SSIs) represent a significant burden in healthcare, commonly occurring after surgical procedures and leading to prolonged recovery times and increased healthcare costs. Traditional antimicrobial dressings pose risks such as antimicrobial resistance. This study aimed to evaluate the safety and clinical efficacy of dialkyl carbamoyl chloride (DACC)-impregnated dressings, which use a purely physical mechanism to prevent bacterial contamination, in patients undergoing orthopaedic or gastrointestinal surgeries. Methods This prospective, multicentre observational study was conducted after ethical committee approval across four centres in India, involving 106 patients (71 orthopaedic and 35 gastrointestinal) who received DACC-impregnated dressings. Dressings were applied immediately post-surgery and assessed over 30 days for the incidence of superficial or deep SSI. Additional evaluations included pain measured using visual analogue scale (VAS), dressing adhesion, patient satisfaction, and healthcare provider feedback. Statistical analyses included descriptive statistics and comparisons between time points using the Wilcoxon and Kruskal-Wallis tests, with a significance level set at p
ISSN:2168-8184
2168-8184
DOI:10.7759/cureus.72654