A systematic review and meta-analysis of the efficacy and safety of traditional Chinese medicine in the treatment of rhinosinusitis

Rhinosinusitis (RS), a common inflammatory disorder, adversely affects quality of life and can progress to serious complications without intervention. Conventional therapies, including antibiotics and corticosteroids, exhibit inherent limitations and risks. Traditional Chinese medicine (TCM), with i...

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Bibliographic Details
Published in:Medicine (Baltimore) 2024-11, Vol.103 (48), p.e40192
Main Authors: Huang, Zhihao, Xuan, Xin, Liu, Shan, Lin, Jinglan, Qian, Zhijun, Chen, Lifen, Qiu, Ruoqing, Cai, Yanwen
Format: Article
Language:English
Subjects:
Drugs, Chinese Herbal - adverse effects
Drugs, Chinese Herbal - therapeutic use
Humans
Medicine, Chinese Traditional - methods
Randomized Controlled Trials as Topic
Rhinitis - drug therapy
Rhinosinusitis
Sinusitis - drug therapy
Systematic Review and Meta-Analysis
Treatment Outcome
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Description
Summary:Rhinosinusitis (RS), a common inflammatory disorder, adversely affects quality of life and can progress to serious complications without intervention. Conventional therapies, including antibiotics and corticosteroids, exhibit inherent limitations and risks. Traditional Chinese medicine (TCM), with its extensive historical use in RS management, remains understudied in contemporary evaluations. This systematic review evaluates the efficacy and safety of TCM in RS treatment, aiming to guide clinical decision-making. A systematic search was undertaken in Chinese and English databases, such as CNKI, Wanfang, VIP, SinoMed, PubMed, Cochrane Library, Web of Science, and other relevant databases, to gather randomized controlled trials of TCM for patients with RS from January 2014 to February 2024. Two researchers independently curated and synthesized data from eligible literature, conducted meta-analyses with ReviewManager 5.4.1, and assessed evidence quality via GRADEPro GDT. A total of 48 articles included 4490 patients, of which 2249 were control group and 2241 were in the experimental group. Meta-analytic outcomes revealed that the integration of TCM with western medicine conventional treatment significantly enhanced the total effective rate [risk ratio=1.20, 95% confidence interval (CI) (1.17, 1.23), P 
ISSN:1536-5964
0025-7974
1536-5964
DOI:10.1097/MD.0000000000040192