Iron changes within infarct tissue in ischemic stroke patients after successful reperfusion quantified using QSM

Purpose For nearly half of patients who undergo Endovascular Thrombectomy following ischemic stroke, successful recanalisation does not guarantee a good outcome. Understanding the underlying tissue changes in the infarct tissue with the help of biomarkers specific to ischemic stroke could offer valu...

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Bibliographic Details
Published in:Neuroradiology 2024-12, Vol.66 (12), p.2233-2242
Main Authors: Kataike, Victoria Mercy, Desmond, Patricia M., Steward, Christopher, Mitchell, Peter J., Davey, Christian, Yassi, Nawaf, Bivard, Andrew, Parsons, Mark W., Campbell, Bruce C.V., Ng, Felix, Venkatraman, Vijay
Format: Article
Language:English
Subjects:
Advanced Neuroimaging
Aged
Biomarkers
Cardiovascular system
Concentration gradient
Female
Humans
Imaging
Iron
Iron - metabolism
Ischemia
Ischemic Stroke - diagnostic imaging
Ischemic Stroke - surgery
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medicine
Medicine & Public Health
Middle Aged
Neurology
Neuroradiology
Neurosciences
Neurosurgery
Patients
Prospective Studies
Radiology
Reperfusion
Reperfusion - methods
Stroke
Tissues
Treatment Outcome
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Summary:Purpose For nearly half of patients who undergo Endovascular Thrombectomy following ischemic stroke, successful recanalisation does not guarantee a good outcome. Understanding the underlying tissue changes in the infarct tissue with the help of biomarkers specific to ischemic stroke could offer valuable insights for better treatment and patient management decisions. Using quantitative susceptibility mapping (QSM) MRI to measure cerebral iron concentration, this study aims to track the progression of iron within the infarct lesion after successful reperfusion. Methods In a prospective study of 87 ischemic stroke patients, successfully reperfused patients underwent MRI scans at 24-to-72 h and 3 months after reperfusion. QSM maps were generated from gradient-echo MRI images. QSM values, measured in parts per billion (ppb), were extracted from ROIs defining the infarct and mirror homolog in the contralateral hemisphere and were compared cross-sectionally and longitudinally. Results QSM values in the infarct ROIs matched those of the contralateral ROIs at 24-to-72 h, expressed as median (interquartile range) ppb [0.71(-7.67-10.09) vs. 2.20(-10.50-14.05) ppb, p  = 0.55], but were higher at 3 months [10.68(-2.30-21.10) vs. -1.27(-12.98-9.82) ppb, p  
ISSN:0028-3940
1432-1920
1432-1920
DOI:10.1007/s00234-024-03444-6