Roles of traditional Chinese medicine extracts in hyperuricemia and gout treatment: Mechanisms and clinical applications

• Published in: World journal of gastroenterology : WJG 2024-12, Vol.30 (47), p.5076-5080
• Main Authors: Wang, Yan-Bo, Jin, Chang-Zhong
• Format: Article
• Language: English
• Subjects: Animals; Drugs, Chinese Herbal - pharmacology; Drugs, Chinese Herbal - therapeutic use; Gastrointestinal Microbiome - drug effects; Gout - drug therapy; Gout Suppressants - therapeutic use; Humans; Hyperuricemia - blood; Hyperuricemia - drug therapy; Letter to the Editor; Medicine, Chinese Traditional - methods; Uric Acid - blood; Uric Acid - metabolism
• ISSN: 1007-9327; 2219-2840; 2219-2840
• DOI: 10.3748/wjg.v30.i47.5076

In this manuscript, we comment on the article by Liu published in the recent issue of the journal. Hyperuricemia (HUA) has become the second most common metabolic disease after type 2 diabetes mellitus and is the most important risk factor for gout. This discussion focuses on the targets and clinical application value of traditional Chinese medicine (TCM) extracts in the treatment of HUA and gout, emphasizing the role of gut microbiota. Liu 's study demonstrated that protein extract alleviated HUA through multiple mechanisms, including inhibition of uric acid (UA) reabsorption, promotion of UA excretion, repair of intestinal barrier function, and regulation of gut microbiota and metabolome. Unlike the commonly used urate-lowering drugs such as allopurinol and febuxostat, which have clear and single targets, many TCMs have multi-target effects. However, the active components and mechanisms of TCMs are not fully understood, limiting their clinical application in the treatment of HUA and gout. Additionally, the role of gut microbiota in UA metabolic homeostasis needs to be further explored.