Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine

Immunophenotypic analysis identified a BM CD57+CXCR3+ subset of CD8+ T cells associated with response to AZA in patients with MDS and AML. Single-cell RNA sequencing analysis revealed that IFN signaling is linked to the response to treatment, whereas TGF-β signaling is associated with treatment fail...

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Published in:Cancer research communications 2024-12, Vol.4 (12), p.3067-3083
Main Authors: Tasis, Athanasios, Papaioannou, Nikos E, Grigoriou, Maria, Paschalidis, Nikolaos, Loukogiannaki, Catherine, Filia, Anastasia, Katsiki, Kyriaki, Lamprianidou, Eleftheria, Papadopoulos, Vasileios, Rimpa, Christina Maria, Chatzigeorgiou, Antonios, Kourtzelis, Ioannis, Gerasimou, Petroula, Kyprianou, Ioannis, Costeas, Paul, Liakopoulos, Panagiotis, Liapis, Konstantinos, Kolovos, Petros, Chavakis, Triantafyllos, Alissafi, Themis, Kotsianidis, Ioannis, Mitroulis, Ioannis
Format: Article
Language:English
Subjects:
Aged
Antimetabolites, Antineoplastic - pharmacology
Antimetabolites, Antineoplastic - therapeutic use
Azacitidine - pharmacology
Azacitidine - therapeutic use
Bone Marrow - drug effects
Bone Marrow - pathology
CD8-Positive T-Lymphocytes - drug effects
CD8-Positive T-Lymphocytes - immunology
Disease Progression
Female
Hematological Cancers
Humans
Immunology
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - immunology
Leukemia, Myeloid, Acute - pathology
Leukemias
Male
Middle Aged
Myelodysplastic Syndromes - drug therapy
Myelodysplastic Syndromes - pathology
Signal Transduction - drug effects
Single Cell Technologies
Single-Cell Analysis
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container_end_page 3083
container_issue 12
container_start_page 3067
container_title Cancer research communications
container_volume 4
creator Tasis, Athanasios
Papaioannou, Nikos E
Grigoriou, Maria
Paschalidis, Nikolaos
Loukogiannaki, Catherine
Filia, Anastasia
Katsiki, Kyriaki
Lamprianidou, Eleftheria
Papadopoulos, Vasileios
Rimpa, Christina Maria
Chatzigeorgiou, Antonios
Kourtzelis, Ioannis
Gerasimou, Petroula
Kyprianou, Ioannis
Costeas, Paul
Liakopoulos, Panagiotis
Liapis, Konstantinos
Kolovos, Petros
Chavakis, Triantafyllos
Alissafi, Themis
Kotsianidis, Ioannis
Mitroulis, Ioannis
description Immunophenotypic analysis identified a BM CD57+CXCR3+ subset of CD8+ T cells associated with response to AZA in patients with MDS and AML. Single-cell RNA sequencing analysis revealed that IFN signaling is linked to the response to treatment, whereas TGF-β signaling is associated with treatment failure, providing insights into new therapeutic approaches.
doi_str_mv 10.1158/2767-9764.CRC-24-0310
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subjects Aged
Antimetabolites, Antineoplastic - pharmacology
Antimetabolites, Antineoplastic - therapeutic use
Azacitidine - pharmacology
Azacitidine - therapeutic use
Bone Marrow - drug effects
Bone Marrow - pathology
CD8-Positive T-Lymphocytes - drug effects
CD8-Positive T-Lymphocytes - immunology
Disease Progression
Female
Hematological Cancers
Humans
Immunology
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - immunology
Leukemia, Myeloid, Acute - pathology
Leukemias
Male
Middle Aged
Myelodysplastic Syndromes - drug therapy
Myelodysplastic Syndromes - pathology
Signal Transduction - drug effects
Single Cell Technologies
Single-Cell Analysis
title Single-Cell Analysis of Bone Marrow CD8+ T Cells in Myeloid Neoplasms Reveals Pathways Associated with Disease Progression and Response to Treatment with Azacitidine
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