Similarities and differences between systemic juvenile idiopathic arthritis and adult-onset Still’s disease: a multicenter Spanish study

• Published in: Rheumatology international 2024-12, Vol.44 (12), p.2911-2920
• Main Authors: Antón, Jordi, Mosquera, Juan Manuel, Calzada, Joan, Iglesias, Estíbaliz, Zacarías, Andrea, Olivé, Alejandro, Bittermann, Violeta, Lorenzo, Tania Rodríguez, Remesal, Agustín, Quintana-Ortega, Cristian, Nuño-Nuño, Laura, Robles-Marhuenda, Angel, de Inocencio, Jaime, Martín-López, María, Carreira, Patricia E., Brandy-García, Anahy M., Holgado, Susana, Camacho-Lovillo, Marisol, Ruiz-Román, Alberto, Clemente, Daniel, Narváez, Javier, Campos, José, Sánchez-Manubens, Judith, Bernabéu, Pilar, Graña, Jenaro, Vargas, Carmen, Ortiz-Santamaria, Vera, Castañeda, Santos, de Yébenes, María Jesús García, Carmona, Loreto
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age of Onset; Arthritis; Arthritis, Juvenile - diagnosis; Arthritis, Juvenile - epidemiology; Child; Disease; Female; Humans; Macrophage Activation Syndrome - diagnosis; Macrophage Activation Syndrome - epidemiology; Macrophage Activation Syndrome - etiology; Male; Medicine; Medicine & Public Health; Middle Aged; Observational Research; Rheumatology; Risk Factors; Serositis - epidemiology; Spain - epidemiology; Still's Disease, Adult-Onset - diagnosis; Still's Disease, Adult-Onset - epidemiology; Young Adult
• ISSN: 1437-160X; 0172-8172; 1437-160X
• DOI: 10.1007/s00296-024-05658-6

To describe the characteristics of systemic juvenile idiopathic arthritis (sJIA) and adult-onset Still’s disease (AOSD), compare their presentation and evolution, and analyse possible complication predictors. Multicenter study. Data were retrieved from a hospital-based study of patients with a diagnosis or suspected diagnosis of sJIA or AOSD according to the responsible physician and followed-up for at least one year. Descriptive variables (classification criteria, clinical manifestations, complications, family, and personal history) were collected at disease onset and during follow-up. We present the clinical characteristics of 326 patients, 67% of whom had a diagnosis of sJIA and 33% of AOSD. Clinical manifestation frequencies were similar between the two groups, except for odynophagia, which was significantly more frequent in AOSD than in sJIA (78.4% vs. 25.5%; p