Pregnancy rate and time to pregnancy after recurrent implantation failure (RIF)—a prospective cohort follow-up study

Purpose The goal of this study was to determine ongoing pregnancy rate, time to pregnancy and embryo transfers to pregnancy within a cohort of patients with recurrent implantation failure (RIF). Methods IVF patients with RIF were included after referral to the RIF outpatient clinic. They received a...

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Bibliographic Details
Published in:Journal of assisted reproduction and genetics 2024-11, Vol.41 (11), p.3061-3070
Main Authors: Stevens Brentjens, Linda B. P. M., Roumen, Relinde J. E., Smits, Luc, Derhaag, Josien, Romano, Andrea, van Golde, Ron J. T., den Hartog, Janneke E.
Format: Article
Language:English
Subjects:
Adult
Assisted Reproduction Technologies
Embryo Implantation
Embryo transfer
Embryo Transfer - methods
Female
Fertilization in Vitro - methods
Follow-Up Studies
Gynecology
Human Genetics
Humans
Implantation
Medicine
Medicine & Public Health
Outpatient care facilities
Patients
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Prospective Studies
Reproductive Medicine
Time-to-Pregnancy
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Summary:Purpose The goal of this study was to determine ongoing pregnancy rate, time to pregnancy and embryo transfers to pregnancy within a cohort of patients with recurrent implantation failure (RIF). Methods IVF patients with RIF were included after referral to the RIF outpatient clinic. They received a questionnaire 1 year after inclusion. If data was missing, medical files were examined to determine pregnancy outcomes and conception methods. The ability of the RIF outpatient clinic to improve pregnancy chance or increase the number of patients who elected to continue treatment was beyond the scope of this study. Results The cumulative incidence of ongoing pregnancy in IVF patients with RIF ( n  = 79) after 1 year of follow-up was 40.5% (95% confidence interval = 30.4–51.5%). Median time to pregnancy was 4 months. Pregnancy incidence increased gradually up to 5 embryo transfers (mostly single embryo transfers). The average embryo transfers to pregnancy were 7.3 transfers. Conclusion In IVF patients with RIF, up until the 5th embryo transfer, each transfer represents a good opportunity for ongoing pregnancy. This data can be used to counsel patients that regular treatment continuation seems to be well justified even when IVF patients fulfil the RIF criteria. Trial registration CCMO: NL66835.068.18. METC 18–040. OMON: NL-OMON24778
ISSN:1058-0468
1573-7330
1573-7330
DOI:10.1007/s10815-024-03257-9