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Assessing corneal dendritic cells in glucose dysregulation small‐fibre neuropathy
Background and Aims Small‐fibre neuropathy (SFN) is associated with glucose dysregulation, including impaired glucose tolerance (IGT) and type 2 diabetes (T2D). Corneal confocal microscopy (CCM) offers a non‐invasive tool to assess corneal nerve damage and dendritic cell density (DCD). In this study...
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| Published in: | Journal of the peripheral nervous system 2024-12, Vol.29 (4), p.400-405 |
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| Main Authors: | , , , |
| Format: | Article |
| Language: | English |
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| container_end_page | 405 |
| container_issue | 4 |
| container_start_page | 400 |
| container_title | Journal of the peripheral nervous system |
| container_volume | 29 |
| creator | Idiaquez, Juan Francisco Barnett‐Tapia, Carolina Perkins, Bruce A. Bril, Vera |
| description | Background and Aims
Small‐fibre neuropathy (SFN) is associated with glucose dysregulation, including impaired glucose tolerance (IGT) and type 2 diabetes (T2D). Corneal confocal microscopy (CCM) offers a non‐invasive tool to assess corneal nerve damage and dendritic cell density (DCD). In this study, we investigated corneal DCD in patients with SFN and glucose dysregulation, defined as IGT or T2D.
Methods
We enrolled 38 patients with SFN + glucose dysregulation, 51 with SFN + non‐glucose dysregulation and 20 healthy controls. All participants underwent neurological examination, neurophysiology and CCM.
Results
Individuals with SFN and glucose dysregulation had higher DCD compared with healthy controls (p = .01), and mature DCD was higher in IGT SFN patients than in T2D patients.
Interpretation
Higher DCD in IGT compared with controls and patients with established T2D may suggest that DCD is a biomarker of early neuropathy. |
| doi_str_mv | 10.1111/jns.12671 |
| format | article |
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Small‐fibre neuropathy (SFN) is associated with glucose dysregulation, including impaired glucose tolerance (IGT) and type 2 diabetes (T2D). Corneal confocal microscopy (CCM) offers a non‐invasive tool to assess corneal nerve damage and dendritic cell density (DCD). In this study, we investigated corneal DCD in patients with SFN and glucose dysregulation, defined as IGT or T2D.
Methods
We enrolled 38 patients with SFN + glucose dysregulation, 51 with SFN + non‐glucose dysregulation and 20 healthy controls. All participants underwent neurological examination, neurophysiology and CCM.
Results
Individuals with SFN and glucose dysregulation had higher DCD compared with healthy controls (p = .01), and mature DCD was higher in IGT SFN patients than in T2D patients.
Interpretation
Higher DCD in IGT compared with controls and patients with established T2D may suggest that DCD is a biomarker of early neuropathy.</description><identifier>ISSN: 1085-9489</identifier><identifier>ISSN: 1529-8027</identifier><identifier>EISSN: 1529-8027</identifier><identifier>DOI: 10.1111/jns.12671</identifier><identifier>PMID: 39532698</identifier><language>eng</language><publisher>Malden, USA: Wiley Periodicals, Inc</publisher><subject>Adult ; Aged ; Cell density ; Confocal microscopy ; Cornea ; Cornea - diagnostic imaging ; Cornea - innervation ; Cornea - pathology ; corneal confocal microscopy ; corneal dendritic cells ; Dendritic Cells ; Diabetes mellitus (non-insulin dependent) ; Diabetes Mellitus, Type 2 - complications ; Diabetic Neuropathies - diagnosis ; Diabetic Neuropathies - metabolism ; Diabetic Neuropathies - pathology ; Diabetic Neuropathies - physiopathology ; Diabetic neuropathy ; Female ; Glucose Intolerance - metabolism ; Glucose tolerance ; Humans ; Immunological tolerance ; impaired glucose tolerance ; Male ; Microscopy, Confocal ; Middle Aged ; Neuropathy ; Research Report ; Small Fiber Neuropathy - diagnosis ; Small Fiber Neuropathy - pathology ; Small Fiber Neuropathy - physiopathology ; small‐fibre neuropathy</subject><ispartof>Journal of the peripheral nervous system, 2024-12, Vol.29 (4), p.400-405</ispartof><rights>2024 The Author(s). published by Wiley Periodicals LLC on behalf of Peripheral Nerve Society.</rights><rights>2024 The Author(s). Journal of the Peripheral Nervous System published by Wiley Periodicals LLC on behalf of Peripheral Nerve Society.</rights><rights>2024. This article is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2991-b84567e1be649d7a7c8286e2effd9ff607a4bf28f4b42d66abcd376b2131e0063</cites><orcidid>0000-0001-5546-0221 ; 0000-0002-5805-4883 ; 0000-0001-9943-8835 ; 0000-0002-5885-0046</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39532698$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Idiaquez, Juan Francisco</creatorcontrib><creatorcontrib>Barnett‐Tapia, Carolina</creatorcontrib><creatorcontrib>Perkins, Bruce A.</creatorcontrib><creatorcontrib>Bril, Vera</creatorcontrib><title>Assessing corneal dendritic cells in glucose dysregulation small‐fibre neuropathy</title><title>Journal of the peripheral nervous system</title><addtitle>J Peripher Nerv Syst</addtitle><description>Background and Aims
Small‐fibre neuropathy (SFN) is associated with glucose dysregulation, including impaired glucose tolerance (IGT) and type 2 diabetes (T2D). Corneal confocal microscopy (CCM) offers a non‐invasive tool to assess corneal nerve damage and dendritic cell density (DCD). In this study, we investigated corneal DCD in patients with SFN and glucose dysregulation, defined as IGT or T2D.
Methods
We enrolled 38 patients with SFN + glucose dysregulation, 51 with SFN + non‐glucose dysregulation and 20 healthy controls. All participants underwent neurological examination, neurophysiology and CCM.
Results
Individuals with SFN and glucose dysregulation had higher DCD compared with healthy controls (p = .01), and mature DCD was higher in IGT SFN patients than in T2D patients.
Interpretation
Higher DCD in IGT compared with controls and patients with established T2D may suggest that DCD is a biomarker of early neuropathy.</description><subject>Adult</subject><subject>Aged</subject><subject>Cell density</subject><subject>Confocal microscopy</subject><subject>Cornea</subject><subject>Cornea - diagnostic imaging</subject><subject>Cornea - innervation</subject><subject>Cornea - pathology</subject><subject>corneal confocal microscopy</subject><subject>corneal dendritic cells</subject><subject>Dendritic Cells</subject><subject>Diabetes mellitus (non-insulin dependent)</subject><subject>Diabetes Mellitus, Type 2 - complications</subject><subject>Diabetic Neuropathies - diagnosis</subject><subject>Diabetic Neuropathies - metabolism</subject><subject>Diabetic Neuropathies - pathology</subject><subject>Diabetic Neuropathies - physiopathology</subject><subject>Diabetic neuropathy</subject><subject>Female</subject><subject>Glucose Intolerance - metabolism</subject><subject>Glucose tolerance</subject><subject>Humans</subject><subject>Immunological tolerance</subject><subject>impaired glucose tolerance</subject><subject>Male</subject><subject>Microscopy, Confocal</subject><subject>Middle Aged</subject><subject>Neuropathy</subject><subject>Research Report</subject><subject>Small Fiber Neuropathy - diagnosis</subject><subject>Small Fiber Neuropathy - pathology</subject><subject>Small Fiber Neuropathy - physiopathology</subject><subject>small‐fibre neuropathy</subject><issn>1085-9489</issn><issn>1529-8027</issn><issn>1529-8027</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><recordid>eNp1kUtuFDEQhi0EIiGw4AKoJTaw6MTl7vZjhaKIpyJYBNaW212eeOSxB7sbNDuOwBk5CR4mRICEN2WpPn2qqp-Qx0BPob6zdSynwLiAO-QYBqZaSZm4W_9UDq3qpToiD0pZUwpCgbpPjjo1dIwreUyuzkvBUnxcNTbliCY0E8Yp-9nbxmIIpfGxWYXFpoLNtCsZV0sws0-xKRsTwo9v350fMzYRl5y2Zr7ePST3nAkFH93UE_Lp1cuPF2_ayw-v316cX7aWKQXtKPuBC4QRea8mYYSVTHJk6NyknONUmH50TLp-7NnEuRnt1Ak-MugAKeXdCXlx8G6XcYOTxThnE_Q2-43JO52M1393or_Wq_RFA3A2KLE3PLsx5PR5wTLrjS_7rU3EtBTdAZNiUEyoij79B12nJce6X6V6BpTDsBc-P1A2p1Jv5W6nAar3Wemalf6VVWWf_Dn-Lfk7nAqcHYCvPuDu_yb97v3VQfkT8FGg9w</recordid><startdate>202412</startdate><enddate>202412</enddate><creator>Idiaquez, Juan Francisco</creator><creator>Barnett‐Tapia, Carolina</creator><creator>Perkins, Bruce A.</creator><creator>Bril, Vera</creator><general>Wiley Periodicals, Inc</general><general>Wiley Subscription Services, Inc</general><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-5546-0221</orcidid><orcidid>https://orcid.org/0000-0002-5805-4883</orcidid><orcidid>https://orcid.org/0000-0001-9943-8835</orcidid><orcidid>https://orcid.org/0000-0002-5885-0046</orcidid></search><sort><creationdate>202412</creationdate><title>Assessing corneal dendritic cells in glucose dysregulation small‐fibre neuropathy</title><author>Idiaquez, Juan Francisco ; Barnett‐Tapia, Carolina ; Perkins, Bruce A. ; Bril, Vera</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2991-b84567e1be649d7a7c8286e2effd9ff607a4bf28f4b42d66abcd376b2131e0063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Cell density</topic><topic>Confocal microscopy</topic><topic>Cornea</topic><topic>Cornea - diagnostic imaging</topic><topic>Cornea - innervation</topic><topic>Cornea - pathology</topic><topic>corneal confocal microscopy</topic><topic>corneal dendritic cells</topic><topic>Dendritic Cells</topic><topic>Diabetes mellitus (non-insulin dependent)</topic><topic>Diabetes Mellitus, Type 2 - complications</topic><topic>Diabetic Neuropathies - diagnosis</topic><topic>Diabetic Neuropathies - metabolism</topic><topic>Diabetic Neuropathies - pathology</topic><topic>Diabetic Neuropathies - physiopathology</topic><topic>Diabetic neuropathy</topic><topic>Female</topic><topic>Glucose Intolerance - metabolism</topic><topic>Glucose tolerance</topic><topic>Humans</topic><topic>Immunological tolerance</topic><topic>impaired glucose tolerance</topic><topic>Male</topic><topic>Microscopy, Confocal</topic><topic>Middle Aged</topic><topic>Neuropathy</topic><topic>Research Report</topic><topic>Small Fiber Neuropathy - diagnosis</topic><topic>Small Fiber Neuropathy - pathology</topic><topic>Small Fiber Neuropathy - physiopathology</topic><topic>small‐fibre neuropathy</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Idiaquez, Juan Francisco</creatorcontrib><creatorcontrib>Barnett‐Tapia, Carolina</creatorcontrib><creatorcontrib>Perkins, Bruce A.</creatorcontrib><creatorcontrib>Bril, Vera</creatorcontrib><collection>Open Access: Wiley-Blackwell Open Access Journals</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of the peripheral nervous system</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Idiaquez, Juan Francisco</au><au>Barnett‐Tapia, Carolina</au><au>Perkins, Bruce A.</au><au>Bril, Vera</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Assessing corneal dendritic cells in glucose dysregulation small‐fibre neuropathy</atitle><jtitle>Journal of the peripheral nervous system</jtitle><addtitle>J Peripher Nerv Syst</addtitle><date>2024-12</date><risdate>2024</risdate><volume>29</volume><issue>4</issue><spage>400</spage><epage>405</epage><pages>400-405</pages><issn>1085-9489</issn><issn>1529-8027</issn><eissn>1529-8027</eissn><abstract>Background and Aims
Small‐fibre neuropathy (SFN) is associated with glucose dysregulation, including impaired glucose tolerance (IGT) and type 2 diabetes (T2D). Corneal confocal microscopy (CCM) offers a non‐invasive tool to assess corneal nerve damage and dendritic cell density (DCD). In this study, we investigated corneal DCD in patients with SFN and glucose dysregulation, defined as IGT or T2D.
Methods
We enrolled 38 patients with SFN + glucose dysregulation, 51 with SFN + non‐glucose dysregulation and 20 healthy controls. All participants underwent neurological examination, neurophysiology and CCM.
Results
Individuals with SFN and glucose dysregulation had higher DCD compared with healthy controls (p = .01), and mature DCD was higher in IGT SFN patients than in T2D patients.
Interpretation
Higher DCD in IGT compared with controls and patients with established T2D may suggest that DCD is a biomarker of early neuropathy.</abstract><cop>Malden, USA</cop><pub>Wiley Periodicals, Inc</pub><pmid>39532698</pmid><doi>10.1111/jns.12671</doi><tpages>6</tpages><orcidid>https://orcid.org/0000-0001-5546-0221</orcidid><orcidid>https://orcid.org/0000-0002-5805-4883</orcidid><orcidid>https://orcid.org/0000-0001-9943-8835</orcidid><orcidid>https://orcid.org/0000-0002-5885-0046</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of the peripheral nervous system, 2024-12, Vol.29 (4), p.400-405 |
| issn | 1085-9489 1529-8027 1529-8027 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection |
| subjects | Adult Aged Cell density Confocal microscopy Cornea Cornea - diagnostic imaging Cornea - innervation Cornea - pathology corneal confocal microscopy corneal dendritic cells Dendritic Cells Diabetes mellitus (non-insulin dependent) Diabetes Mellitus, Type 2 - complications Diabetic Neuropathies - diagnosis Diabetic Neuropathies - metabolism Diabetic Neuropathies - pathology Diabetic Neuropathies - physiopathology Diabetic neuropathy Female Glucose Intolerance - metabolism Glucose tolerance Humans Immunological tolerance impaired glucose tolerance Male Microscopy, Confocal Middle Aged Neuropathy Research Report Small Fiber Neuropathy - diagnosis Small Fiber Neuropathy - pathology Small Fiber Neuropathy - physiopathology small‐fibre neuropathy |
| title | Assessing corneal dendritic cells in glucose dysregulation small‐fibre neuropathy |
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