The performance of a new rapid interferon gamma release assay based on fluorescence immunochromatography for Mycobacterium tuberculosis infection testing in village doctors in China

The AIMTB rapid test assay is an emerging test, which adopted a fluorescence immunochromatographic assay to measure interferon-γ (IFN-γ) production following stimulation of effector memory T cells in whole blood by mycobacterial proteins. The aim of this article was to explore the ability of AIMTB r...

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Bibliographic Details
Published in:Epidemiology and infection 2024-11, Vol.152, p.e155-19
Main Authors: Cao, Xuefang, Chen, Yanxiao, Xin, Henan, Du, Jiang, Feng, Boxuan, He, Yijun, Guo, Tonglei, Shen, Lingyu, Di, Yuanzhi, Liang, Jianguo, Li, Zihan, Zhang, Bin, Wang, Dakuan, Liu, Zisen, Duan, Weitao, Jin, Qi, Gao, Lei
Format: Article
Language:English
Subjects:
Adult
Aged
Alcohol use
Antigens
Assaying
Bioassays
Body mass index
China - epidemiology
Chromatography
Chromatography, Affinity - methods
Effector cells
Female
Fluorescence
Humans
Immunization
Immunological memory
Infections
Interferon
Interferon-gamma Release Tests - methods
Lymphocytes
Lymphocytes T
Male
Medical treatment
Memory cells
Middle Aged
Mycobacterium tuberculosis
Mycobacterium tuberculosis - immunology
Mycobacterium tuberculosis - isolation & purification
Original Paper
Overweight
Physicians
Population
Population studies
Rural Population
Software
Statistical analysis
Tuberculosis
Tuberculosis - diagnosis
Young Adult
γ-Interferon
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Summary:The AIMTB rapid test assay is an emerging test, which adopted a fluorescence immunochromatographic assay to measure interferon-γ (IFN-γ) production following stimulation of effector memory T cells in whole blood by mycobacterial proteins. The aim of this article was to explore the ability of AIMTB rapid test assay in detecting Mycobacterium tuberculosis (MTB) infection compared with the widely applied QuantiFERON-TB Gold Plus (QFT-Plus) test among rural doctors in China. In total, 511 participants were included in the survey. The concordance between the QFT-Plus test and the AIMTB rapid test assay was 94.47% with a Cohen’s kappa coefficient (κ) of 0.84 (95% CI, 0.79–0.90). Improved concordance between the two tests was observed in males and in participants with 26 or more years of service as rural doctors. The quantitative values of the QFT-Plus test was higher in individuals with a result of QFT-Plus-/AIMTB+ as compared to those with a result of QFT-Plus-/AIMTB- (p 
ISSN:0950-2688
1469-4409
1469-4409
DOI:10.1017/S0950268824001146