Gut Microbiome and Pulmonary Arterial Hypertension – A Novel and Evolving Paradigm

Pulmonary arterial hypertension is characterized by perivascular and systemic inflammation. The gut microbiome influences the host immune system. Here we review the emerging preclinical and clinical evidence that strongly suggests that alterations in the gut microbiome may either initiate or facilit...

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Bibliographic Details
Published in:Physiological research 2024-11, Vol.73 (Suppl 2), p.S477-S485
Main Authors: Thenappan, T, Weir, EK
Format: Article
Language:English
Subjects:
Bacteria
Disease
Extracellular matrix
FDA approval
Homeostasis
Hypertension
Hypoxia
Immune response
Immune system
Inflammation
Intestinal microflora
Invited Review
Lung diseases
Lungs
Lymphocytes
Medical prognosis
Metabolites
Microbiomes
Mortality
Pathogenesis
Pre-eclampsia
Pulmonary arteries
Pulmonary hypertension
Vascular diseases
Citations: Items that this one cites
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Description
Summary:Pulmonary arterial hypertension is characterized by perivascular and systemic inflammation. The gut microbiome influences the host immune system. Here we review the emerging preclinical and clinical evidence that strongly suggests that alterations in the gut microbiome may either initiate or facilitate progression of established pulmonary arterial hypertension by modifying the systemic immune responses. We also briefly review the relationship between the gut microbiome and preeclampsia, a vascular disease also characterized by inflammation.
ISSN:0862-8408
1802-9973
DOI:10.33549/physiolres.935430