In Vitro Hepatic Metabolism Input Parameters Support Toxicokinetic Simulations for the Formation of Methoxy Propionic Acid From β‐Isomer Propylene Glycol Methyl Ether

ABSTRACT Propylene glycol ethers (PGEs) are organic solvents commonly found as technical grade on the commercial market, as mixtures of secondary (α‐isomer) and primary (β‐isomer, generally

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Bibliographic Details
Published in:Pharmacology research & perspectives 2024-12, Vol.12 (6), p.e70037-n/a
Main Authors: Werner, Sophie, Hegg, Lucie, Hopf, Nancy B., Borgatta, Myriam, Suter‐Dick, Laura
Format: Article
Language:English
Subjects:
Acids
Alcohol
Alcohol Dehydrogenase - metabolism
Aldehyde Dehydrogenase - metabolism
Carbon dioxide
Cell culture
Cell Line
Chromatography
Computer Simulation
Cytochrome
Dehydrogenases
Enzymes
Hepatocytes - drug effects
Hepatocytes - metabolism
Humans
Isomerism
Liver
Liver - drug effects
Liver - metabolism
Metabolism
Metabolites
Models, Biological
Neurotoxicity
Original
Propionates - chemistry
Propionates - metabolism
Propylene Glycol - chemistry
Solvents
Spectrum analysis
Toxicity
Toxicokinetics
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Summary:ABSTRACT Propylene glycol ethers (PGEs) are organic solvents commonly found as technical grade on the commercial market, as mixtures of secondary (α‐isomer) and primary (β‐isomer, generally
ISSN:2052-1707
2052-1707
DOI:10.1002/prp2.70037