Volumetric development of hippocampal subfields and hippocampal white matter connectivity: Relationship with episodic memory

The hippocampus is a complex structure composed of distinct subfields. It has been central to understanding neural foundations of episodic memory. In the current cross‐sectional study, using a large sample of 830, 3‐ to 21‐year‐olds from a unique, publicly available dataset we examined the following...

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Bibliographic Details
Published in:Developmental psychobiology 2022-12, Vol.64 (8), p.e22333-n/a
Main Authors: Dick, Anthony Steven, Ralph, Yvonne, Farrant, Kristafor, Reeb‐Sutherland, Bethany, Pruden, Shannon, Mattfeld, Aaron T.
Format: Article
Language:English
Subjects:
cingulum
Cross-Sectional Studies
episodic memory
fornix
Hippocampus - diagnostic imaging
hippocampus development
Magnetic Resonance Imaging
medial temporal lobe
Memory, Episodic
uncinate fasciculus
White Matter - diagnostic imaging
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Summary:The hippocampus is a complex structure composed of distinct subfields. It has been central to understanding neural foundations of episodic memory. In the current cross‐sectional study, using a large sample of 830, 3‐ to 21‐year‐olds from a unique, publicly available dataset we examined the following questions: (1) Is there elevated grey matter volume of the hippocampus and subfields in late compared to early development? (2) How does hippocampal volume compare with the rest of the cerebral cortex at different developmental stages? and (3) What is the relation between hippocampal volume and connectivity with episodic memory performance? We found hippocampal subfield volumes exhibited a nonlinear relation with age and showed a lag in volumetric change with age when compared to adjacent cortical regions (e.g., entorhinal cortex). We also observed a significant reduction in cortical volume across older cohorts, while hippocampal volume showed the opposite pattern. In addition to age‐related differences in gray matter volume, dentate gyrus/cornu ammonis 3 volume was significantly related to episodic memory. We did not, however, find any associations with episodic memory performance and connectivity through the uncinate fasciculus, fornix, or cingulum. The results are discussed in the context of current research and theories of hippocampal development and its relation to episodic memory.
ISSN:0012-1630
1098-2302
1098-2302
DOI:10.1002/dev.22333