Serum Level of RIPK1/3 Correlated With the Prognosis in ICU Patients With Acute Ischemic Stroke

Acute ischemic stroke (AIS) is a common cerebrovascular disease with high mortality. AIS patients in the intensive care unit (ICU) often have severe conditions that require close monitoring and timely treatment. Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 play important roles in cell apo...

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Bibliographic Details
Published in:Immunity, Inflammation and Disease Inflammation and Disease, 2024-12, Vol.12 (12), p.e70085
Main Authors: Dong, Jianhong, Xiong, Xinli
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Female
Humans
Intensive Care Units - statistics & numerical data
Ischemic Stroke - blood
Ischemic Stroke - diagnosis
Ischemic Stroke - mortality
Male
Middle Aged
Original
Prognosis
Receptor-Interacting Protein Serine-Threonine Kinases - blood
Retrospective Studies
ROC Curve
Severity of Illness Index
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Summary:Acute ischemic stroke (AIS) is a common cerebrovascular disease with high mortality. AIS patients in the intensive care unit (ICU) often have severe conditions that require close monitoring and timely treatment. Receptor-interacting protein kinase 1 (RIPK1) and RIPK3 play important roles in cell apoptosis and inflammation. However, the relevance of serum RIPK1/3 to AIS patients in the ICU has not been clarified. To explore the correlation of serum RIPK1 and RIPK3 with the prognosis of AIS patients in the ICU. One hundred and twenty AIS patients were selected as the research subjects for the retrospective analysis. The subjects were grouped based on the volume of cerebral infarction and the score of the National Institute of Health Stroke Scale (NIHSS) and mRS. The correlation was explored using Pearson analysis. The predictive value was valued using the ROC curve. The content of serum RIPK1 and RIPK3 was gradually elevated with increased cerebral infarction volume and the severity of the disease (p 
ISSN:2050-4527
2050-4527
DOI:10.1002/iid3.70085