Inhibition of lipid peroxidation by the iron-binding protein lactoferrin

Lactoferrin containing physiological amounts of iron is an inhibitor of lipid peroxidation induced by iron(III) salts and ascorbic acid. It might therefore help to protect neutrophils, inflammatory foci and secretions from metal-ion-dependent oxidative damage.

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Bibliographic Details
Published in:Biochemical journal 1981-10, Vol.199 (1), p.259-261
Main Authors: Gutteridge, J M, Paterson, S K, Segal, A W, Halliwell, B
Format: Article
Language:English
Subjects:
Animals
Ascorbic Acid - pharmacology
Cattle
Ferric Compounds - pharmacology
Humans
Lactoferrin - metabolism
Lactoferrin - pharmacology
Lactoglobulins - pharmacology
Lipid Metabolism
Liposomes - metabolism
Peptide and Protein Structure
Protein Binding
Proteins - pharmacology
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Description
Summary:Lactoferrin containing physiological amounts of iron is an inhibitor of lipid peroxidation induced by iron(III) salts and ascorbic acid. It might therefore help to protect neutrophils, inflammatory foci and secretions from metal-ion-dependent oxidative damage.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj1990259