Identifying dose constraints for the parotid ducts to minimize patient‐reported xerostomia: Is conventional mean dose sparing of the parotid glands sufficient?

Background and purpose The aim of this study was to identify dose constraints for the parotid ducts that limit patient‐reported xerostomia and estimate whether these constraints are achieved during conventional parotid gland sparing radiation therapy (PGS‐RT). Methods and materials Thirty‐eight orop...

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied clinical medical physics 2024-12, Vol.25 (12), p.e14515-n/a
Main Authors: Ahmidouch, Manal, Das, Shiva K., Zhu, Tong, Shen, Colette, Marks, Lawrence B., Chera, Bhishamjit S., Fried, David V.
Format: Article
Language:English
Subjects:
Aged
Carcinoma, Squamous Cell - radiotherapy
dose constraint
Dosimetry
Exocrine glands
Female
Humans
IMRT
Magnetic Resonance Imaging - methods
Male
Medical imaging
Middle Aged
Organ Sparing Treatments - methods
Organs at Risk - radiation effects
Oropharyngeal Neoplasms - radiotherapy
parotid
Parotid Gland - diagnostic imaging
Parotid Gland - radiation effects
Patients
Prognosis
Prospective Studies
Radiation Oncology Physics
Radiation therapy
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy, Intensity-Modulated - adverse effects
Radiotherapy, Intensity-Modulated - methods
Retrospective Studies
Simulation
Squamous cell carcinoma
Toxicity
xerostomia
Xerostomia - etiology
Xerostomia - prevention & control
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background and purpose The aim of this study was to identify dose constraints for the parotid ducts that limit patient‐reported xerostomia and estimate whether these constraints are achieved during conventional parotid gland sparing radiation therapy (PGS‐RT). Methods and materials Thirty‐eight oropharyngeal squamous cell carcinoma patients were treated prospectively on trial with MRI sialography‐guided parotid duct sparing radiation therapy (PDS‐RT). PDS‐RT explicitly minimizes dose to the parotid ducts in addition to PGS‐RT. Parotid duct dose constraints were identified that distinguished patients reporting high and low rates of xerostomia. Atlas‐based parotid duct contours were generated on a retrospective cohort of similar patients where the parotid ducts were not contoured nor explicitly spared to estimate the dose received by the parotid ducts during PGS‐RT. Results Patients whose intraglandular parotid ducts or total parotid ducts were planned for a mean dose 
ISSN:1526-9914
1526-9914
DOI:10.1002/acm2.14515