Association Between Serum Ustekinumab Concentrations and Endoscopic Disease Activity in Moderate-to-Severe Crohn's Disease Patients

The role of ustekinumab therapeutic drug monitoring in patients with Crohn's disease (CD) remains ambiguous. Examination of the association serum ustekinumab concentrations and endoscopic outcomes has yielded inconsistent results. Our study examined whether serum ustekinumab concentrations were...

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Bibliographic Details
Published in:Crohn's & colitis 360 2024-10, Vol.6 (4), p.otae071
Main Authors: Di Fonzo, David M P, Alabdulkarim, Balqis, Yanofsky, Russell, Abduallah, Yaqeen, Golovics, Petra, Lakatos, Peter L, Bitton, Alain, Wild, Gary, Afif, Waqqas, Bessissow, Talat
Format: Article
Language:English
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Observations and Research
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Summary:The role of ustekinumab therapeutic drug monitoring in patients with Crohn's disease (CD) remains ambiguous. Examination of the association serum ustekinumab concentrations and endoscopic outcomes has yielded inconsistent results. Our study examined whether serum ustekinumab concentrations were associated with endoscopic healing in patients with moderate-to-severe CD. This was a cross-sectional study of adult patients with CD on maintenance ustekinumab. Patients were included if they had serum ustekinumab concentrations and endoscopic evaluation taken within 4 months of each other. Endoscopic healing was defined as absence of ulceration on endoscopy or Simplified Endoscopic Score for Crohn's disease (SES-CD) 
ISSN:2631-827X
2631-827X
DOI:10.1093/crocol/otae071