Comparison of clinical characteristics and pathologic complete response rate after neoadjuvant chemotherapy in women under 35 years and older women with breast cancer

Age has been confirmed as a very aggressive biological factor associated with the poor prognosis of breast cancer (BC) patients. However, the understanding of young women with breast cancer (YWBC) is scarce. This study compares and evaluates the clinical characteristics and pathologic complete respo...

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Published in:Gland surgery 2024-11, Vol.13 (11), p.1907-1920
Main Authors: Dou, He, Gao, Tian, Li, Zhaoting, Jia, Siyuan, Luo, Danli, Ba, Yuling, Li, Fucheng, Wang, Jianan, Xiao, Min
Format: Article
Language:English
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Summary:Age has been confirmed as a very aggressive biological factor associated with the poor prognosis of breast cancer (BC) patients. However, the understanding of young women with breast cancer (YWBC) is scarce. This study compares and evaluates the clinical characteristics and pathologic complete response (pCR) rate after neoadjuvant chemotherapy (NAC) in YWBC and older women with BC. We retrospectively analyzed the clinicopathological data and pCR rates of 1,419 non-metastatic BC patients from the Harbin Medical University Cancer Hospital from 1 January 2012 to 31 December 2019. Patients were classified according to age (≤35 >35 years old) with the clinical parameters. The chi-squared or Fisher's exact test was used to evaluate the correlation between clinicopathological variables and pCR. Any predictor variables with P15% were more likely to achieve pCR (P
ISSN:2227-684X
2227-8575
DOI:10.21037/gs-24-293