The Effectiveness of Ebselen in Facial Nerve Crush Injury: An Experimental Study

BACKGROUND: Ebselen is a neuroprotective drug that protects cellular components from oxidative damage by modulating enzymatic cofactors, metalloproteins, gene expression, antio xidan t-ant i-inf lamma tory effects, and immunological systems. Our goal was to compare the efficacy of Ebselen and methyl...

Full description

Saved in:
Bibliographic Details
Published in:The journal of international advanced otology 2024-11, Vol.20 (6), p.507-516
Main Authors: Seneldir, Lutfu, Golcuk, Veysel Alparslan, Toker, Gokce Tanyeri, Verim, Aysegul, Gunes, Pembegul
Format: Article
Language:English
Subjects:
Anesthesia
Antioxidants
Corticosteroids
Enzymes
Gene expression
Humidity
Immunology
Injuries
Kinases
Laboratory animals
Medical research
Medicine
Methylprednisolone
Original
Paresis
Side effects
Steroids
Surgery
Trauma
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:BACKGROUND: Ebselen is a neuroprotective drug that protects cellular components from oxidative damage by modulating enzymatic cofactors, metalloproteins, gene expression, antio xidan t-ant i-inf lamma tory effects, and immunological systems. Our goal was to compare the efficacy of Ebselen and methylprednisolone on rat facial nerve crush injury. METHODS: Thirty healthy male Wistar rats (mean weight of 245 g) were used in this study. The rats were randomly divided into four groups: Group 1 (ebselen group), Group 2 (methylprednisolone group), Group 3 (control group), and Group 4 (sham group (the right side of the control group)). Except for the sham group, all groups had their left facial nerve crushed. Three weeks after surgery, prospective functional, histologic, and electrophysiologic recovery was reported. RESULTS: The ebselen group and methylprednisolone group had similar and more significant recovery at Nerve Excitability Thresholds (NET) at the end of three weeks. These groups also showed similar features in terms of histopathological parameters such as axonal degeneration, vascular congestion, axon diameter, and myelin thickness. Except for the macrovacuolization parameter, both showed statistically better results than the control group. Although there was an earlier improvement in the whiskers and blink tests in the ebselen group compared to the methylprednisolone and control groups, complete recovery was observed in all groups on the 21st day. CONCLUSION: Ebselen was found to be similarly effective to methylprednisolone in nerve regeneration in a rat model of experimental facial nerve crush. Considering that methylprednisolone has serious systemic side effects, ebselen may be a good alternative. KEYWORDS: Facial nerve, crush injury, neuroprotective agents, methylprednisolone, ebselen, experimental rat model
ISSN:1308-7649
2148-3817
DOI:10.5152/iao.2024.231360