A model for cytoplasm-governed gene regulation

A model of cytoplasm-governed transcription is presented. The nuclear membrane has a selective permeability towards nuclear pre-mRNA molecules which are provided with group-specific non-translated "passwords". RNA transcription on the chromatin proceeds under a dual control. One of them is...

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Bibliographic Details
Published in:Biochemical journal 1976-12, Vol.159 (3), p.783-794
Main Authors: Lichtenstein, A V, Shapot, V S
Format: Article
Language:English
Subjects:
Biological Transport
Cell Membrane Permeability
Cell Nucleus
Chromatin
Cytoplasm
Models, Biological
Nucleic Acid Hybridization
RNA, Messenger
Transcription, Genetic
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Summary:A model of cytoplasm-governed transcription is presented. The nuclear membrane has a selective permeability towards nuclear pre-mRNA molecules which are provided with group-specific non-translated "passwords". RNA transcription on the chromatin proceeds under a dual control. One of them is gene regulation according to the Britten-Davidson and Georgiev models. The other is cytoplasm-governed regulation mediated through the selective transport of mRNA from nucleus to cytoplasm. Pre-mRNA molecules which are not "in immediate demand" by the cytoplasm and therefore accumulating the nucleus repress their own synthesis by end-product inhibition. The interrelationship of the two types of regulation in the course of cell development is discussed.
ISSN:0264-6021
1470-8728
DOI:10.1042/bj1590783