Acute effects in vivo of anti-insulin serum on rates of fatty acid synthesis and activities of acetyl-coenzyme A carboxylase and pyruvate dehydrogenase in liver and epididymal adipose tissue of fed rats

Plasma insulin concentrations in fed rats were altered acutely by administration of glucose or anti-insulin serum. Rates of fatty acid synthesis in adipose tissue and liver were estimated from the incorporation of 3H from 3H2O. In the adipose tissue dehydrogenase and acetyl-CoA carboxylase were evid...

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Bibliographic Details
Published in:Biochemical journal 1976-11, Vol.160 (2), p.413-416
Main Authors: Stansbie, D, Brownsey, R W, Crettaz, M, Denton, R M
Format: Article
Language:English
Subjects:
Acetyl-CoA Carboxylase - metabolism
Adipose Tissue - enzymology
Adipose Tissue - metabolism
Animals
Fatty Acids - biosynthesis
Glucose - pharmacology
Insulin - blood
Insulin - immunology
Ligases - metabolism
Liver - enzymology
Liver - metabolism
Male
Pyruvate Dehydrogenase Complex - metabolism
Rats
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Summary:Plasma insulin concentrations in fed rats were altered acutely by administration of glucose or anti-insulin serum. Rates of fatty acid synthesis in adipose tissue and liver were estimated from the incorporation of 3H from 3H2O. In the adipose tissue dehydrogenase and acetyl-CoA carboxylase were evident. In liver, although changes in rates of fatty acid synthesis were found, the initial activity of pyruvate dehydrogenase did not alter, but small parallel changes in acetyl-CoA carboxylase activity were observed.
ISSN:0264-6021
0306-3283
1470-8728
DOI:10.1042/bj1600413