Relationship Between Serum Vitamin D Levels and Chronic Musculoskeletal Pain in Adults: A Systematic Review

Chronic pain impacts approximately 18% of the Spanish population, with low levels of vitamin D prevalent in over 80% of individuals over 65. Given vitamin D's critical role in pain modulation, its deficiency may be significantly linked to chronic musculoskeletal pain, though existing research o...

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Bibliographic Details
Published in:Nutrients 2024-11, Vol.16 (23), p.4061
Main Authors: Alonso-Pérez, José Luís, Martínez-Pérez, Iker, Romero-Morales, Carlos, Abuín-Porras, Vanesa, López-Bueno, Ruben, Rossettini, Giacomo, Leigheb, Massimiliano, Villafañe, Jorge Hugo
Format: Article
Language:English
Subjects:
Adult
Adults
Aged
Alfacalcidol
Calcifediol
Care and treatment
Chronic pain
Chronic Pain - blood
Data analysis
Dietary Supplements
Female
Fibromyalgia
Health aspects
Humans
Investigations
Male
Middle Aged
Muscle strength
Musculoskeletal Pain - blood
Musculoskeletal Pain - epidemiology
Observational studies
Pain
Quality of life
Questionnaires
Review
Systematic review
Vitamin D
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - epidemiology
Vitamin deficiency
Women
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Summary:Chronic pain impacts approximately 18% of the Spanish population, with low levels of vitamin D prevalent in over 80% of individuals over 65. Given vitamin D's critical role in pain modulation, its deficiency may be significantly linked to chronic musculoskeletal pain, though existing research offers mixed results. This systematic review followed PRISMA guidelines, examining studies from PubMed, Cochrane, and PEDRO databases from 1990 onwards that investigated the relationship between vitamin D levels and chronic musculoskeletal pain. A total of 30 studies met the inclusion criteria set by the NHLBI's quality standards. The results are inconclusive regarding the direct relationship between vitamin D levels and chronic musculoskeletal pain due to evidence heterogeneity. However, there appears to be an inverse relationship between vitamin D levels and the intensity of pain. While the association between vitamin D levels and chronic musculoskeletal pain remains uncertain, the inverse correlation with pain intensity suggests a potential therapeutic role of vitamin D supplementation in pain management. Further research is needed to substantiate these findings and refine intervention strategies.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu16234061