Coriandrum sativum L. Leaf Extract Ameliorates Metabolic Dysfunction-Associated Steatotic Liver Disease by Modulating the AMPK Pathway in High Fat-Fed C57BL/6 Mice

• Published in: Nutrients 2024-11, Vol.16 (23), p.4165
• Main Authors: Gu, Min Ji, Ahn, Yejin, Lee, Yu Ra, Yoo, Guijae, Kim, Yoonsook, Choi, Inwook, Ha, Sang Keun, Kim, Donghwan
• Format: Article
• Language: English
• Subjects: Amino acids; AMP-Activated Protein Kinases - metabolism; Animals; Antibodies; Cholesterol; Chromatography; Coriandrum - chemistry; Diabetes; Diet; Diet, High-Fat - adverse effects; Disease Models, Animal; FDA approval; Gene expression; Inflammation; Kinases; Lipid Metabolism - drug effects; Liver - drug effects; Liver - metabolism; Liver diseases; Male; Medicine, Botanic; Medicine, Herbal; Membranes; Metabolism; Metabolites; Mice; Mice, Inbred C57BL; Non-alcoholic Fatty Liver Disease - drug therapy; Non-alcoholic Fatty Liver Disease - etiology; Non-alcoholic Fatty Liver Disease - metabolism; Nutrition research; Plant Extracts - pharmacology; Plant Leaves - chemistry; Prevention; Signal Transduction - drug effects; Tumor necrosis factor-TNF; Type 2 diabetes; Weight control
• ISSN: 2072-6643; 2072-6643
• DOI: 10.3390/nu16234165

Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease. In recent times, the term NAFLD has been modified to metabolic dysfunction-associated steatotic liver disease (MASLD), reflecting its comprehensive scope encompassing a range of metabolic abnormalities. L. (CS) is a traditional medicine, although the preventive mechanism of CS extracts remains unclear. This study evaluated the preventive effects of CS in high-fat diet (HFD)-induced MASLD mice by oral administration of 100 or 200 mg/kg/day of CS extracts for 12 weeks. The major CS extract compounds were chlorogenic acid, caffeic acid, rutin, and isoquercetin. The administration of CS extract suppressed HFD-induced weight gain, liver weight, and the liver/body weight ratio. It improved the mice's serum biological profiles and suppressed HFD-induced lipid droplet and lipid accumulation by inhibiting lipid accumulation-related gene expression in the liver. It modulated HFD-induced Ampk-Srebp1c pathways and suppressed HFD-induced NF-κB pathway activation in the liver. It regulated inflammation and the AMPK alpha signaling pathway in HFD-fed mice by reducing the accumulation of specific amino acids, leading to the amelioration of fatty liver. The CS extract prevents HFD-induced MASLD and may help prevent or treat MASLD.