Talimogene laherparepvec (T-VEC) and Emerging Intralesional Immunotherapies for Metastatic Melanoma: A Review

Purpose of review As the incidence of cutaneous melanoma continues to rise worldwide, its heterogeneous presentation proves challenging for managing and preventing relapse. Recent findings While surgery remains a mainstay in staging and treatment of locoregional metastatic melanoma, intralesional th...

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Published in:Current oncology reports 2024-12, Vol.26 (12), p.1651-1663
Main Authors: Kalsi, Simran, Galenkamp, Amanda L., Singh, Rohit, Khosla, Atulya Aman, McGranaghan, Peter, Cintolo-Gonzalez, Jessica
Format: Article
Language:English
Subjects:
Adjuvants
Biological Products - therapeutic use
Cytokines
Drug dosages
Herpes viruses
Herpesvirus 1, Human
Humans
Hydrogels
Illnesses
Immunity (Disease)
Immunomodulation
Immunotherapy
Immunotherapy - methods
Injections, Intralesional
Lymphatic system
Lymphocytes
Medicine
Medicine & Public Health
Melanoma
Melanoma - immunology
Melanoma - therapy
Metastases
Metastasis
Oncology
Oncolytic Virotherapy - methods
Review
Reviews
Skin Neoplasms - immunology
Skin Neoplasms - pathology
Skin Neoplasms - therapy
Topical Collection on Melanoma
Toxicity
Citations: Items that this one cites
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Summary:Purpose of review As the incidence of cutaneous melanoma continues to rise worldwide, its heterogeneous presentation proves challenging for managing and preventing relapse. Recent findings While surgery remains a mainstay in staging and treatment of locoregional metastatic melanoma, intralesional therapies have emerged as a new tool to treat unresectable in-transit and nodal metastases and reduce the risk of relapse through immunomodulatory mechanisms. Summary In this review, we will provide an overview of intralesional therapies for melanoma with a particular focus on talimogene laherparepvec (T-VEC) and its future uses. We then discuss the landscape of current and emerging intralesional therapies.
ISSN:1523-3790
1534-6269
1534-6269
DOI:10.1007/s11912-024-01611-9