Health utilities of patients with epilepsy in a Canadian population

Objective Health state utilities are required to obtain quality adjusted life years, a common metric that informs clinical decision‐making at individual, group, and health policy levels. Health state utilities are different from health‐related quality of life, and their distribution across patients...

Full description

Saved in:
Bibliographic Details
Published in:Epilepsia (Copenhagen) 2024-12, Vol.65 (12), p.3526-3535
Main Authors: Arimoro, Olayinka I., Wiebe, Samuel, Lin, Chantelle Q. Y., Josephson, Colin B., Sajobi, Tolulope T.
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Anticonvulsants
Canada - epidemiology
Decision making
Demography
Epilepsy
Epilepsy - epidemiology
Epilepsy - psychology
EQ‐5D‐5L
Female
health state utility
Health Status
health‐related quality of life
Humans
Male
Middle Aged
Patients
Quality of Life
Quality-Adjusted Life Years
Retrospective Studies
Seizures
Young Adult
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective Health state utilities are required to obtain quality adjusted life years, a common metric that informs clinical decision‐making at individual, group, and health policy levels. Health state utilities are different from health‐related quality of life, and their distribution across patients with epilepsy, as well as the factors that impact them, have not been studied in depth. We aimed to describe the distribution of health state utilities in people with epilepsy and the impact of different combinations of clinical and demographic factors on health state evaluation. Methods We performed a retrospective analysis of patients' data prospectively collected in the Calgary Comprehensive Epilepsy Program registry. Patient‐reported health state utilities were measured using the 5‐level EuroQol 5‐Dimension scale (EQ‐5D‐5L) completed at their initial assessment. EQ‐5D‐5L index scores were derived via the time trade‐off approach based on Canadian norms, and their distribution across different health states and patient characteristics was obtained. The Tobit regression model was used to evaluate the determinants of EQ‐5D‐5L index scores. Results Of 1446 patients included in this analysis, 724 (50.5%) were female. The median (interquartile range) Canada‐normed EQ‐5D‐5L index score was .87 (.71–.91). Patients with significantly lower health utilities were more likely to be female (p = .008), to be older (p = .034), to be unmarried (p = .013), to have failed to achieve 1‐year seizure freedom (p 
ISSN:0013-9580
1528-1167
1528-1167
DOI:10.1111/epi.18132