Outcome of Liver Retransplantation in Patients With Primary Sclerosing Cholangitis

ABSTRACT Background and Aims Primary sclerosing cholangitis (PSC) is among the most common indications for liver transplantation in the Nordic countries and with an increasing trend in Europe and North America. Due to post‐transplant complications and high prevalence of disease recurrence this group...

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Bibliographic Details
Published in:Liver international 2025-01, Vol.45 (1), p.e16214-n/a
Main Authors: Molinaro, Antonio, Engesæter, Lise Katrine, Jorns, Carl, Nordin, Arno, Rasmussen, Allan, Line, Pål‐Dag, Pall, Virge, Ericzon, Bo‐Göran, Bennet, William, Hov, Johannes R., Melum, Espen
Format: Article
Language:English
Subjects:
Adult
Cholangitis
Cholangitis, Sclerosing - complications
Cholangitis, Sclerosing - mortality
Cholangitis, Sclerosing - surgery
Female
Graft rejection
Graft Survival
Grafting
Humans
Liver
Liver diseases
Liver transplantation
Liver Transplantation - adverse effects
Liver Transplantation - mortality
Male
Medical prognosis
Middle Aged
Original
Patients
Population studies
primary sclerosing cholangitis
Recurrence
Registries
Reoperation
retransplantation
Retrospective Studies
Scandinavian and Nordic Countries - epidemiology
Survival
Transplants & implants
Treatment Outcome
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Summary:ABSTRACT Background and Aims Primary sclerosing cholangitis (PSC) is among the most common indications for liver transplantation in the Nordic countries and with an increasing trend in Europe and North America. Due to post‐transplant complications and high prevalence of disease recurrence this group is at risk of requiring retransplantation (re‐LTX). Results from re‐LTX for PSC are not extensively studied and there is a lack of knowledge regarding prognosis after re‐LTX in this population. Methods Graft and patient survival after re‐LTX for patients with PSC and a comparable comparison group from the Nordic liver transplant registry were analysed. One‐hundred and eighty‐five patients with PSC and 208 patients in the comparison group were included. Results The graft and patient survival were better for patients with PSC compared to the comparison group (p 
ISSN:1478-3223
1478-3231
1478-3231
DOI:10.1111/liv.16214