Altered Hippocampal Subfields Functional Connectivity in Benign Paroxysmal Positional Vertigo Patients With Residual Dizziness: A Resting-State fMRI Study

• Published in: CNS neuroscience & therapeutics 2024-12, Vol.30 (12), p.e70175
• Main Authors: Chen, Zhengwei, Xiao, Lijie, Liu, Yueji, Wei, Xiue, Wang, Zhuo, Cao, Xingyi, Liu, Haiyan, Zhai, Yujia, Rong, Liangqun
• Format: Article
• Language: English
• Subjects: Adult; Aged; Benign Paroxysmal Positional Vertigo - diagnostic imaging; Benign Paroxysmal Positional Vertigo - physiopathology; Dizziness - diagnostic imaging; Dizziness - physiopathology; Female; Hippocampus - diagnostic imaging; Hippocampus - physiopathology; Humans; Magnetic Resonance Imaging; Male; Middle Aged; Nerve Net - diagnostic imaging; Nerve Net - physiopathology; Neural Pathways - diagnostic imaging; Neural Pathways - physiopathology; Original; Rest
• ISSN: 1755-5949; 1755-5930; 1755-5949
• DOI: 10.1111/cns.70175

To explore alterations in functional connectivity (FC) focusing on hippocampal subfields in benign paroxysmal positional vertigo (BPPV) patients with residual dizziness (RD) after successful canalith repositioning procedure (CRP). We conducted resting-state functional magnetic resonance imaging (fMRI) on 95 BPPV patients, comprising 50 patients with RD and 45 without. Seed-to-voxel and seed-to-seed analyses were employed to examine changes in FC between the two groups. The hippocampal subfields, including the bilateral dentate gyrus (DG), cornu ammonis (CA), entorhinal cortex (EC), subiculum, and hippocampal amygdalar transition area (HATA) were selected as seeds. Additionally, we assessed the relationship between abnormal FC and clinical symptoms. Seed-to-voxel analysis indicated that, compared to non-RD patients, those with RD exhibited decreased FC between the right DG and right parietal operculum cortex, right HATA and right precuneus, left HATA and left precuneus, left EC and cerebellar vermis 8/-crus 1, and between the left subiculum and left angular gyrus. Conversely, we observed increased FC between the left CA and left lingual gyrus, as well as between the right CA and right fusiform gyrus in RD patients. Furthermore, these variations in FC were significantly correlated with clinical features including the duration of RD and scores on the Hamilton Anxiety Scale and Dizziness Handicap Inventory. BPPV patients with RD exhibited altered FC between hippocampal subfields and brain regions associated with spatial orientation and navigation, vestibular and visual processing, and emotional regulation. These findings offer novel insights into the pathophysiological mechanisms in BPPV patients with RD following successful CRP.