Oculomotor nerve palsy recovery following microsurgery vs. endovascular treatment of posterior communicating artery aneurysms: a comparative meta-analysis of short- and long-term outcomes

• Published in: Neurosurgical review 2024-12, Vol.47 (1), p.904
• Main Authors: Abo Kasem, Rahim, Cunningham, Conor, Elawady, Sameh Samir, Sowlat, Mohammad Mahdi, Babool, Sofia, Hulou, Saad, Hubbard, Zachary, Orscelik, Atakan, Musmar, Basel, Spiotta, Alejandro M.
• Format: Article
• Language: English
• Subjects: Endovascular Procedures - methods; Humans; Intracranial Aneurysm - complications; Intracranial Aneurysm - surgery; Medicine; Medicine & Public Health; Microsurgery - methods; Neurosurgery; Neurosurgical Procedures - methods; Oculomotor Nerve Diseases - etiology; Oculomotor Nerve Diseases - surgery; Recovery of Function; Review; Treatment Outcome
• ISSN: 1437-2320; 0344-5607; 1437-2320
• DOI: 10.1007/s10143-024-03149-7

Recent advancements in endovascular treatment (EVT) and different views on optimal management for posterior communicating artery (PComA) aneurysms with oculomotor nerve palsy (ONP) highlight a need to compare recovery timelines between microsurgery and EVT; heterogeneous outcomes and influencing factors may also affect results. A comprehensive systematic review and meta-analysis were conducted by searching PubMed, Embase, Scopus, and Web of Science databases. The extracted data encompassed patient demographics, details on treatment modalities and timing, and characteristics of PComA aneurysms ONP caused by either unruptured or ruptured aneurysms. The primary outcome was ONP favorable recovery, defined as the resolution of admission symptoms, except for subtle ptosis and mild pupillary asymmetry. We used random effect models to calculate odds ratios (OR) and pool prevalence with their corresponding 95% confidence intervals (CI). A total of 40 studies met the inclusion criteria. Overall, microsurgical clipping of PComA aneurysms demonstrated a significantly higher likelihood of ONP recovery compared to EVT at 1,3,6, and 12 months follow-up. However, recovery rates were comparable in long-term follow-up [18 months: (0.87 vs. 0.64, P-value = 0.36); ≥24 months: (0.86 vs. 0.72 P-Value = 0.26)]. The recovery outcomes for early treatment were similar when assessed during the 6-month follow-up (0.75 vs. 0.56, P-value = 0.07). Our findings suggest microsurgery leads to prompt ONP recovery from PComA aneurysms, while EVT shows potential for delayed favorable recovery; both treatments yield short-term recovery when administered early. A case-by-case approach is recommended, emphasizing a comprehensive understanding of patient factors in relation to the immediate and sustained effects of each treatment.