Pulmonary involvement in newly diagnosed and untreated rheumatoid arthritis and psoriatic arthritis: a prospective longitudinal study

Objectives To longitudinally assesses pulmonary involvement in newly diagnosed rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients over a 12-months follow-up. To identify biomarkers and establish a diagnostic algorithm for monitoring pulmonary changes. Methods Newly diagnosed RA and PsA...

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Bibliographic Details
Published in:Rheumatology international 2024-12, Vol.45 (1), p.3, Article 3
Main Authors: Winter, Lone, Petzinna, Simon M., Skowasch, Dirk, Pizarro, Carmen, Weber, Marcel, Kütting, Daniel, Behning, Charlotte, Bauer, Claus-Jürgen, Schäfer, Valentin S.
Format: Article
Language:English
Subjects:
Adult
Aged
Arthritis, Psoriatic - diagnosis
Arthritis, Rheumatoid - complications
Arthritis, Rheumatoid - diagnosis
Arthritis, Rheumatoid - drug therapy
Arthritis, Rheumatoid - physiopathology
Asymptomatic
Biomarkers
Biomarkers - blood
Case-Control Studies
Disease Progression
Female
Humans
Longitudinal Studies
Lung - diagnostic imaging
Lung - physiopathology
Lung Diseases - diagnosis
Lung Diseases - etiology
Lung Diseases - physiopathology
Male
Medicine
Medicine & Public Health
Middle Aged
Observational Research
Prospective Studies
Psoriatic arthritis
Radiography, Thoracic
Respiratory Function Tests
Rheumatoid arthritis
Rheumatology
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Summary:Objectives To longitudinally assesses pulmonary involvement in newly diagnosed rheumatoid arthritis (RA) and psoriatic arthritis (PsA) patients over a 12-months follow-up. To identify biomarkers and establish a diagnostic algorithm for monitoring pulmonary changes. Methods Newly diagnosed RA and PsA patients were examined with clinical and laboratory assessments, pulmonary function tests (PFT), and chest radiography (CXR) at three-months intervals for one year. Results The study enrolled 50 patients (26 RA, 24 PsA) and 26 controls. At baseline, 37.0% of arthritis patients (50.0% RA, 22.7% PsA) exhibited radiographic pulmonary involvement, with 64.7% being asymptomatic. No association was observed between CXR and PFTs. Reduced pathological breathing width was noted in 64.0% of patients (RA 69.2%, PsA 58.3%) and 23.1% of controls ( p  
ISSN:1437-160X
0172-8172
1437-160X
DOI:10.1007/s00296-024-05751-w