cfDNA fragmentation patterns correlate with tumor burden measured via PSMA PET/CT volumetric parameters in patients with biochemical recurrence of prostate cancer

Background Prostate cancer recurrence following primary treatment poses a significant clinical challenge, particularly when detected through biochemical recurrence at low PSA levels. Conventional imaging modalities often fail to localize the disease at this early stage. PSMA PET has demonstrated sup...

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Bibliographic Details
Published in:EJNMMI research 2024-12, Vol.14 (1), p.124
Main Authors: Amseian, Gary, Figueras, Marcel, Mases, Joel, Mengual, Lourdes, Ribal, Maria-Jose, Quintero, Katherine, Pages, Rita, Ingelmo-Torres, Mercedes, Roldan, Fiorella-Lizzeth, Caratini, Rocío, Fuster, David, Alcaraz, Antonio, Izquierdo, Laura, Paredes, Pilar
Format: Article
Language:English
Subjects:
Biochemistry
Biomarkers
Biopsy
Cardiac Imaging
Computed tomography
Correlation coefficients
Fragmentation
Imaging
Medical imaging
Medicine
Medicine & Public Health
Nuclear Medicine
Oncology
Original Research
Orthopedics
Parameter sensitivity
Positron emission
Prostate cancer
Radiology
Tumors
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Summary:Background Prostate cancer recurrence following primary treatment poses a significant clinical challenge, particularly when detected through biochemical recurrence at low PSA levels. Conventional imaging modalities often fail to localize the disease at this early stage. PSMA PET has demonstrated superior sensitivity in detecting recurrent lesions, even in patients with low PSA. Concurrently, liquid biopsy, through analysis of cell-free DNA (cfDNA), offers a minimally invasive approach for monitoring disease. There is scarce evidence about the association between liquid biopsy and PSMA PET/CT findings. This study aimed to assess the correlation between liquid biopsy and tumor burden assessed by PSMA PET/CT in early recurring prostate cancer patients. Results PSMA PET/CT and liquid biopsies of 32 patients in biochemical recurrence were analyzed. 12 patients (37.5%) had no PSMA PET-measurable disease. Four patients (12.5%) presented local recurrence, seven (21.9%) had recurrence in pelvic lymph nodes, one of whom also had local recurrence. Nine patients (28.1%) presented metastatic recurrence, with or without local or nodal recurrence. PSA levels correlated with molecular imaging data ( p  
ISSN:2191-219X
2191-219X
DOI:10.1186/s13550-024-01170-x