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Mendelian randomization analyses support causal relationships between HPV infection and colorectal cancer
Background Human Papillomavirus (HPV) infections leading to a variety of diseases are a global public health issue.Despite the well-established link between HPV infection and cervical and anogenital cancers, there is ongoing debate regarding the relationship between HPV infection and colorectal canc...
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| Published in: | Discover. Oncology 2024-12, Vol.15 (1), p.795 |
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| Language: | English |
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| container_title | Discover. Oncology |
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| creator | Pei, Bo Liu, Peijun Peng, Shixuan Zhou, Fuxiang |
| description | Background
Human Papillomavirus (HPV) infections leading to a variety of diseases are a global public health issue.Despite the well-established link between HPV infection and cervical and anogenital cancers, there is ongoing debate regarding the relationship between HPV infection and colorectal cancer (CRC).
Methods
We evaluated the causal connection between HPV infection and CRC utilizing five Mendelian randomization (MR) methods. Genome-wide association studies (GWAS) datasets for HPV were obtained from the IEU Open GWAS project. A large summary of colorectal adenocarcinoma and colorectal cancer data from the FinnGen database was used as the outcome.
Results
Our analysis revealed a significant association between genetically predicted HPV-16 infection and the risk of paternal colorectal adenocarcinoma (HPV-16: OR 1.058, 95% CI 1.013–1.102;
p
= 0.011), as well as CRC (HPV-16: OR 1.045, 95% CI 1.005–1.085;
p
= 0.025).
Conclusion
These findings provide compelling evidence for a causal effect of HPV infection on the development of CRC. Further investigations into the underlying mechanisms and elucidation of this association are necessary to identify viable interventions for the prevention and treatment of HPV-associated CRC. |
| doi_str_mv | 10.1007/s12672-024-01639-0 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_11656272</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3146647212</sourcerecordid><originalsourceid>FETCH-LOGICAL-p1840-59643286649f5d5ce79792b953e11532bb21d7ea3c431c905fa98c9fe008e4943</originalsourceid><addsrcrecordid>eNpdkU9PFjEQhzdGIwT4Ah5MEy9eFqf_tydjiAIJBg_qtel2Z6Gkb7u2uxj89Cy8r4qeppN55pdJn6Z5ReGYAuh3lTKlWQtMtEAVNy08a_aZ5tAqoPT5k_dec1TrDQAwSTkH-bLZ40YZpjvYb8JnTAPG4BIpLg15E365OeREXHLxrmIldZmmXGbi3VJdJAXjI1Cvw1RJj_NPxETOvnwnIY3od7sD8TnmsvbrinfJYzlsXowuVjza1YPm26ePX0_O2ovL0_OTDxftRDsBrTRKcNYpJcwoB-lRG21YbyRHSiVnfc_ooNFxLzj1BuToTOfNiAAdCiP4QfN-mzst_QYHj2kuLtqphI0rdza7YP-dpHBtr_KtpVRJxTRbE97uEkr-sWCd7SZUjzG6hHmpllOhjBRUmhV98x96k5eyft2WUkIz-hD4-ulJf275rWEF-Bao6yhdYfkbQ8E--LZb33b1bR99W-D3oNecHQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3146647212</pqid></control><display><type>article</type><title>Mendelian randomization analyses support causal relationships between HPV infection and colorectal cancer</title><source>PubMed Central Free</source><source>Publicly Available Content Database</source><creator>Pei, Bo ; Liu, Peijun ; Peng, Shixuan ; Zhou, Fuxiang</creator><creatorcontrib>Pei, Bo ; Liu, Peijun ; Peng, Shixuan ; Zhou, Fuxiang</creatorcontrib><description>Background
Human Papillomavirus (HPV) infections leading to a variety of diseases are a global public health issue.Despite the well-established link between HPV infection and cervical and anogenital cancers, there is ongoing debate regarding the relationship between HPV infection and colorectal cancer (CRC).
Methods
We evaluated the causal connection between HPV infection and CRC utilizing five Mendelian randomization (MR) methods. Genome-wide association studies (GWAS) datasets for HPV were obtained from the IEU Open GWAS project. A large summary of colorectal adenocarcinoma and colorectal cancer data from the FinnGen database was used as the outcome.
Results
Our analysis revealed a significant association between genetically predicted HPV-16 infection and the risk of paternal colorectal adenocarcinoma (HPV-16: OR 1.058, 95% CI 1.013–1.102;
p
= 0.011), as well as CRC (HPV-16: OR 1.045, 95% CI 1.005–1.085;
p
= 0.025).
Conclusion
These findings provide compelling evidence for a causal effect of HPV infection on the development of CRC. Further investigations into the underlying mechanisms and elucidation of this association are necessary to identify viable interventions for the prevention and treatment of HPV-associated CRC.</description><identifier>ISSN: 2730-6011</identifier><identifier>EISSN: 2730-6011</identifier><identifier>DOI: 10.1007/s12672-024-01639-0</identifier><identifier>PMID: 39692780</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Analysis ; Cancer Research ; Colorectal cancer ; Genomes ; Human papillomavirus ; Infections ; Internal Medicine ; Medicine ; Medicine & Public Health ; Molecular Medicine ; Oncology ; Proteins ; Radiotherapy ; Risk factors ; Sensitivity analysis ; Surgical Oncology ; Viruses</subject><ispartof>Discover. Oncology, 2024-12, Vol.15 (1), p.795</ispartof><rights>The Author(s) 2024</rights><rights>2024. The Author(s).</rights><rights>Copyright Springer Nature B.V. Dec 2024</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/3146647212/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/3146647212?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,37013,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39692780$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pei, Bo</creatorcontrib><creatorcontrib>Liu, Peijun</creatorcontrib><creatorcontrib>Peng, Shixuan</creatorcontrib><creatorcontrib>Zhou, Fuxiang</creatorcontrib><title>Mendelian randomization analyses support causal relationships between HPV infection and colorectal cancer</title><title>Discover. Oncology</title><addtitle>Discov Onc</addtitle><addtitle>Discov Oncol</addtitle><description>Background
Human Papillomavirus (HPV) infections leading to a variety of diseases are a global public health issue.Despite the well-established link between HPV infection and cervical and anogenital cancers, there is ongoing debate regarding the relationship between HPV infection and colorectal cancer (CRC).
Methods
We evaluated the causal connection between HPV infection and CRC utilizing five Mendelian randomization (MR) methods. Genome-wide association studies (GWAS) datasets for HPV were obtained from the IEU Open GWAS project. A large summary of colorectal adenocarcinoma and colorectal cancer data from the FinnGen database was used as the outcome.
Results
Our analysis revealed a significant association between genetically predicted HPV-16 infection and the risk of paternal colorectal adenocarcinoma (HPV-16: OR 1.058, 95% CI 1.013–1.102;
p
= 0.011), as well as CRC (HPV-16: OR 1.045, 95% CI 1.005–1.085;
p
= 0.025).
Conclusion
These findings provide compelling evidence for a causal effect of HPV infection on the development of CRC. Further investigations into the underlying mechanisms and elucidation of this association are necessary to identify viable interventions for the prevention and treatment of HPV-associated CRC.</description><subject>Analysis</subject><subject>Cancer Research</subject><subject>Colorectal cancer</subject><subject>Genomes</subject><subject>Human papillomavirus</subject><subject>Infections</subject><subject>Internal Medicine</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Molecular Medicine</subject><subject>Oncology</subject><subject>Proteins</subject><subject>Radiotherapy</subject><subject>Risk factors</subject><subject>Sensitivity analysis</subject><subject>Surgical Oncology</subject><subject>Viruses</subject><issn>2730-6011</issn><issn>2730-6011</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNpdkU9PFjEQhzdGIwT4Ah5MEy9eFqf_tydjiAIJBg_qtel2Z6Gkb7u2uxj89Cy8r4qeppN55pdJn6Z5ReGYAuh3lTKlWQtMtEAVNy08a_aZ5tAqoPT5k_dec1TrDQAwSTkH-bLZ40YZpjvYb8JnTAPG4BIpLg15E365OeREXHLxrmIldZmmXGbi3VJdJAXjI1Cvw1RJj_NPxETOvnwnIY3od7sD8TnmsvbrinfJYzlsXowuVjza1YPm26ePX0_O2ovL0_OTDxftRDsBrTRKcNYpJcwoB-lRG21YbyRHSiVnfc_ooNFxLzj1BuToTOfNiAAdCiP4QfN-mzst_QYHj2kuLtqphI0rdza7YP-dpHBtr_KtpVRJxTRbE97uEkr-sWCd7SZUjzG6hHmpllOhjBRUmhV98x96k5eyft2WUkIz-hD4-ulJf275rWEF-Bao6yhdYfkbQ8E--LZb33b1bR99W-D3oNecHQ</recordid><startdate>20241218</startdate><enddate>20241218</enddate><creator>Pei, Bo</creator><creator>Liu, Peijun</creator><creator>Peng, Shixuan</creator><creator>Zhou, Fuxiang</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>C6C</scope><scope>NPM</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20241218</creationdate><title>Mendelian randomization analyses support causal relationships between HPV infection and colorectal cancer</title><author>Pei, Bo ; Liu, Peijun ; Peng, Shixuan ; Zhou, Fuxiang</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p1840-59643286649f5d5ce79792b953e11532bb21d7ea3c431c905fa98c9fe008e4943</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Analysis</topic><topic>Cancer Research</topic><topic>Colorectal cancer</topic><topic>Genomes</topic><topic>Human papillomavirus</topic><topic>Infections</topic><topic>Internal Medicine</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Molecular Medicine</topic><topic>Oncology</topic><topic>Proteins</topic><topic>Radiotherapy</topic><topic>Risk factors</topic><topic>Sensitivity analysis</topic><topic>Surgical Oncology</topic><topic>Viruses</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pei, Bo</creatorcontrib><creatorcontrib>Liu, Peijun</creatorcontrib><creatorcontrib>Peng, Shixuan</creatorcontrib><creatorcontrib>Zhou, Fuxiang</creatorcontrib><collection>Springer Nature OA Free Journals</collection><collection>PubMed</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Discover. Oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pei, Bo</au><au>Liu, Peijun</au><au>Peng, Shixuan</au><au>Zhou, Fuxiang</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Mendelian randomization analyses support causal relationships between HPV infection and colorectal cancer</atitle><jtitle>Discover. Oncology</jtitle><stitle>Discov Onc</stitle><addtitle>Discov Oncol</addtitle><date>2024-12-18</date><risdate>2024</risdate><volume>15</volume><issue>1</issue><spage>795</spage><pages>795-</pages><issn>2730-6011</issn><eissn>2730-6011</eissn><abstract>Background
Human Papillomavirus (HPV) infections leading to a variety of diseases are a global public health issue.Despite the well-established link between HPV infection and cervical and anogenital cancers, there is ongoing debate regarding the relationship between HPV infection and colorectal cancer (CRC).
Methods
We evaluated the causal connection between HPV infection and CRC utilizing five Mendelian randomization (MR) methods. Genome-wide association studies (GWAS) datasets for HPV were obtained from the IEU Open GWAS project. A large summary of colorectal adenocarcinoma and colorectal cancer data from the FinnGen database was used as the outcome.
Results
Our analysis revealed a significant association between genetically predicted HPV-16 infection and the risk of paternal colorectal adenocarcinoma (HPV-16: OR 1.058, 95% CI 1.013–1.102;
p
= 0.011), as well as CRC (HPV-16: OR 1.045, 95% CI 1.005–1.085;
p
= 0.025).
Conclusion
These findings provide compelling evidence for a causal effect of HPV infection on the development of CRC. Further investigations into the underlying mechanisms and elucidation of this association are necessary to identify viable interventions for the prevention and treatment of HPV-associated CRC.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>39692780</pmid><doi>10.1007/s12672-024-01639-0</doi><oa>free_for_read</oa></addata></record> |
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| ispartof | Discover. Oncology, 2024-12, Vol.15 (1), p.795 |
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| language | eng |
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| subjects | Analysis Cancer Research Colorectal cancer Genomes Human papillomavirus Infections Internal Medicine Medicine Medicine & Public Health Molecular Medicine Oncology Proteins Radiotherapy Risk factors Sensitivity analysis Surgical Oncology Viruses |
| title | Mendelian randomization analyses support causal relationships between HPV infection and colorectal cancer |
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