Application of apparent diffusion coefficient of extraocular muscles from diffusion tensor imaging scanning in the assessment of disease activity of thyroid eye disease

To evaluate the utility of apparent diffusion coefficient (ADC) values of extraocular muscles (EOMs) in differentiating activity of thyroid eye disease (TED). Forty-two TED patients who underwent diffusion tensor imaging(DTI) were retrospectively enrolled in this study, including 29 patients in anal...

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Bibliographic Details
Published in:BMC endocrine disorders 2024-12, Vol.24 (1), p.276
Main Authors: Tang, Cheng Yang, Huang, Qian, Liang, Liang, Zhang, Ming Qiao, Zheng, Xiao Ya, Long, Jian
Format: Article
Language:English
Subjects:
Adult
Aged
Diffusion Tensor Imaging - methods
Female
Follow-Up Studies
Graves Ophthalmopathy - diagnostic imaging
Humans
Male
Middle Aged
Oculomotor Muscles - diagnostic imaging
Oculomotor Muscles - pathology
Prognosis
Retrospective Studies
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Summary:To evaluate the utility of apparent diffusion coefficient (ADC) values of extraocular muscles (EOMs) in differentiating activity of thyroid eye disease (TED). Forty-two TED patients who underwent diffusion tensor imaging(DTI) were retrospectively enrolled in this study, including 29 patients in analysis group and 13 patients in validation group. The mean, maximum and minimum ADC value of each EOM were regarded as ADCmean, ADCmax and ADCmin. The difference between ADCmax and ADCmin was regarded as △ADC. The correlations between ADCmean or △ADC of each EOM and clinical activity score (CAS) were assessed. In analysis group, ADCmean differed between active and inactive eyes and positively correlated with CAS in IR (P  0.05). While △ADC differed between two groups and negatively correlated with CAS in all EOMs (all P 
ISSN:1472-6823
1472-6823
DOI:10.1186/s12902-024-01818-8