Myeloperoxidase and Thyrotropin‐Releasing Hormone Within Leukaemia Stem Cells Increased Chemosensitivity in Acute Myeloid Leukaemia

ABSTRACT Leukaemia stem cells (LSCs) are major contributors to chemoresistance in acute myeloid leukaemia (AML). Identifying potential biomarkers within LSCs that can predict chemosensitivity in AML is key. This prospective study involved 20 consecutive de novo AML patients who underwent ‘7 + 3’ ind...

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Published in:Journal of cellular and molecular medicine 2024-12, Vol.28 (24), p.e70306-n/a
Main Authors: Chen, Chung‐Hsing, Chen, Tsung‐Chih, Wu, Ting‐Shuan, Hsiao, Tzu‐Hung, Chen, Jo‐Mei Maureen, Huang, Chi‐Ying F., Cheng, Po‐Liang, Tsai, Jia‐Rung, Teng, Chieh‐Lin Jerry
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Adult
Aged
AML
Biomarkers
Biomarkers, Tumor - metabolism
Bone marrow
Chemoresistance
chemosensitivity
Chemotherapy
Cytogenetics
Datasets
Dendritic cells
Drug Resistance, Neoplasm
Female
Genes
Genomes
Genomics
Hemopoiesis
Humans
Induction therapy
leukaemic stem cells
Leukemia
Leukemia, Myeloid, Acute - drug therapy
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - metabolism
Leukemia, Myeloid, Acute - pathology
Leukocytes (mononuclear)
Male
Medical prognosis
Middle Aged
MPO
Neoplastic Stem Cells - drug effects
Neoplastic Stem Cells - metabolism
Neoplastic Stem Cells - pathology
Original
Peroxidase
Peroxidase - metabolism
Phosphorylation
Prognosis
Prospective Studies
Stem cells
Thyroid-stimulating hormone
Transforming growth factor-a
TRH
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Summary:ABSTRACT Leukaemia stem cells (LSCs) are major contributors to chemoresistance in acute myeloid leukaemia (AML). Identifying potential biomarkers within LSCs that can predict chemosensitivity in AML is key. This prospective study involved 20 consecutive de novo AML patients who underwent ‘7 + 3’ induction therapy. The patients were divided into CR (n = 15) and non‐CR (n = 5) groups. Using single‐cell RNA sequencing, we examined the cellular states of bone marrow mononuclear cells from AML patients at diagnosis and identified LSC among these cells. Our results showed that in non‐CR AML patients, a significant increase in the proportion of immature cells during haematopoiesis within the AML cell populations was observed. Moreover, the expression of myeloperoxidase (MPO) (log2 fold‐change = 0.89; adjusted p 
ISSN:1582-1838
1582-4934
1582-4934
DOI:10.1111/jcmm.70306