Intracellular α-synuclein assemblies are sufficient to alter nanoscale diffusion in the striatal extracellular space

α-synucleinopathies progression involves the spread of α-synuclein aggregates through the extracellular space (ECS). Single-particle tracking studies showed that α-synuclein-induced neurodegeneration increases ECS molecular diffusivity. To disentangle the consequences of neuronal loss versus α-synuc...

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Published in:NPJ Parkinson's Disease 2024-12, Vol.10 (1), p.236, Article 236
Main Authors: Estaun-Panzano, J., Nandi, S., Gresil, Q., Doudnikoff, E., Mazzocco, C., Arotcarena, ML, Canron, MH, Dehay, B., Cognet, L., Bezard, E.
Format: Article
Language:English
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631/378/1689/1718
631/378/87
Biomedical and Life Sciences
Biomedicine
Brief Communication
Neurology
Neurosciences
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Summary:α-synucleinopathies progression involves the spread of α-synuclein aggregates through the extracellular space (ECS). Single-particle tracking studies showed that α-synuclein-induced neurodegeneration increases ECS molecular diffusivity. To disentangle the consequences of neuronal loss versus α-synuclein-positive intracellular assemblies formation, we performed near-infrared single-particle tracking to characterise ECS rheology in the striatum of mouse models of α-synucleinopathies. We showed that intracellular α-synuclein assemblies, without neurodegeneration, suffice to alter nanoscale diffusion in the striatal ECS.
ISSN:2373-8057
2373-8057
DOI:10.1038/s41531-024-00850-8