Portulaca oleracea Extract Ameliorates Testosterone Propionate-Induced Benign Prostatic Hyperplasia in Male Sprague-Dawley Rats

Benign prostatic hyperplasia (BPH) is a distressing health problem that can cause serious complications in aging men. Androgens are implicated in the causation of BPH. Portulaca oleracea (PO) is a natural product with diverse pharmacological effects. The objective of this study was to investigate th...

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Published in:Veterinary medicine and science 2025-01, Vol.11 (1), p.e70184
Main Authors: Lim, Young-Ju, Kim, Hye Rim, Lee, Seul Bi, Kim, Sang Back, Kim, Dong-Hee, So, Jae-Hyun, Kang, Kyung-Ku, Sung, Soo-Eun, Choi, Joo-Hee, Sung, Minkyoung, Lee, Yeon-Ji, Park, Wook-Tae, Lee, Gun Woo, Kim, Seul-Ki, Seo, Min-Soo
Format: Article
Language:English
Subjects:
Animals
Finasteride - pharmacology
Male
Original
Plant Extracts - administration & dosage
Plant Extracts - pharmacology
Portulaca - chemistry
Prostatic Hyperplasia - chemically induced
Prostatic Hyperplasia - drug therapy
Prostatic Hyperplasia - veterinary
Rats
Rats, Sprague-Dawley
Testosterone Propionate
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Summary:Benign prostatic hyperplasia (BPH) is a distressing health problem that can cause serious complications in aging men. Androgens are implicated in the causation of BPH. Portulaca oleracea (PO) is a natural product with diverse pharmacological effects. The objective of this study was to investigate the effect of PO in a rat model of testosterone propionate (TP)-induced BPH and explore the underlying mechanisms. Thirty-five Sprague-Dawley (SD) rats were divided into the following equal groups (n = 7): normal control (NC) group, TP (3 mg/kg) group, finasteride (10 mg/kg) group, 25 and 50 mg/kg PO groups. At the end of the experiment, the body weights (BWs) of the rats were measured before they were euthanized to the establishment obtain serum and prostate weight (PW). TP-induced levels of androgen-related proteins in the prostate were also investigated. In the TP group, prostate size, BW, serum DHT level, prostate epithelial cell thickness and androgen-related protein level were higher than those in the NC group (p 
ISSN:2053-1095
2053-1095
DOI:10.1002/vms3.70184