The additive effect of the stress hyperglycemia ratio on type 2 diabetes: a population-based cohort study

The stress hyperglycemia ratio (SHR) has recently gained attention as a marker for acute hyperglycemia, which has been linked to adverse clinical outcomes. However, its independent role in the development of type 2 diabetes (T2D) remains understudied. This cohort study aimed to assess the associatio...

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Bibliographic Details
Published in:Cardiovascular diabetology 2025-01, Vol.24 (1), p.5-7, Article 5
Main Authors: Cui, Cancan, Song, Jiayin, Zhang, Lingyu, Han, Ning, Xu, Wanqi, Sheng, Chen, Xin, Guangda, Cui, Xiaofeng, Yu, Lili, Liu, Lin
Format: Article
Language:English
Subjects:
Aged
Biomarkers - blood
Blood Glucose - metabolism
China - epidemiology
Diabetes
Diabetes Mellitus, Type 2 - blood
Diabetes Mellitus, Type 2 - diagnosis
Diabetes Mellitus, Type 2 - epidemiology
Female
Glucose
Glycated Hemoglobin - metabolism
HbA1c
Humans
Hyperglycemia - blood
Hyperglycemia - diagnosis
Hyperglycemia - epidemiology
Incidence
Longitudinal Studies
Male
Middle Aged
Prognosis
Risk Assessment
Risk Factors
Stress hyperglycemia ratio (SHR)
Time Factors
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Summary:The stress hyperglycemia ratio (SHR) has recently gained attention as a marker for acute hyperglycemia, which has been linked to adverse clinical outcomes. However, its independent role in the development of type 2 diabetes (T2D) remains understudied. This cohort study aimed to assess the association between SHR and the incidence of T2D. The study included 8978 participants aged 45 or older, free of diabetes at baseline, from the China Health and Retirement Longitudinal Study (CHARLS). Incident T2D up to December 31, 2020, was the primary outcome. Participants were divided into SHR quartiles, and Cox proportional hazards regression and fine-gray competing risk models were used to assess SHR's association with T2D onset, adjusting for fasting glucose and HbA1c. The mean age of participants was 59.0 ± 9.5 years, and 51.5% were women. Over a mean follow-up of 7.8 years, 1084 participants developed T2D. Cox regression analysis revealed that individuals in the highest SHR quartile had a significantly higher risk of T2D onset compared to those in the lowest quartile (HR 1.48, 95% CI 1.26-1.75, P for trend 
ISSN:1475-2840
1475-2840
DOI:10.1186/s12933-024-02567-7