Transducing Hedgehog: the story so far

The secreted proteins of the Hedgehog family have been implicated in many different processes in vertebrate development including cartilage differentiation, myotome and sclerotome specification, hair follicle development, limb morphogenesis and the specification of different neuronal cell types. In...

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Bibliographic Details
Published in:The EMBO journal 1998-07, Vol.17 (13), p.3505-3511
Main Author: Ingham, P. W.
Format: Article
Language:English
Subjects:
Animals
basal cell carcinoma
Drosophila Proteins
EMBO Member's Review
hedgehog
Hedgehog Proteins
Humans
Insect Proteins - genetics
Insect Proteins - metabolism
Membrane Proteins - metabolism
Patched Receptors
Proteins - genetics
Proteins - metabolism
Receptors, Cell Surface - metabolism
Receptors, G-Protein-Coupled
Signal Transduction
signalling
Smoothened Receptor
Trans-Activators
tumour suppressor
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Description
Summary:The secreted proteins of the Hedgehog family have been implicated in many different processes in vertebrate development including cartilage differentiation, myotome and sclerotome specification, hair follicle development, limb morphogenesis and the specification of different neuronal cell types. In addition, the aberrant activation of the Hedgehog pathway has been identified as the likely cause of a number of tumours in humans including basal cell carcinomas (BCCs) and primitive neurectodermal tumours (PNETs). Elucidating the mechanisms by which Hedgehog signals are transduced will thus have widespread implications for our understanding of both normal development and disease.
ISSN:0261-4189
1460-2075
1460-2075
DOI:10.1093/emboj/17.13.3505