Effect Of Horseradish (Moringa Oleifera) Seeds on Biochemical and Molecular Parameters in Paraquat‐Induced Parkinson Disease‐Like Symptoms in Fruit Flies

Background In recent decades, epidemiological and experimental studies have looked into the role of pesticides, particularly the herbicide paraquat, in the development of Parkinson’s disease. Horseradish tree (Moringa oleifera) is an ethnobotanical plant with lots of therapeutic potential, but there...

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Bibliographic Details
Published in:Alzheimer's & dementia 2024-12, Vol.20 (S6), p.n/a
Main Authors: Aro, Olayemi Philemon, Adefegha, Adeniyi Stephen, Ogunsuyi, Opeyemi Babatunde, Oboh, Ganiyu
Format: Article
Language:English
Subjects:
Drug Development
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Summary:Background In recent decades, epidemiological and experimental studies have looked into the role of pesticides, particularly the herbicide paraquat, in the development of Parkinson’s disease. Horseradish tree (Moringa oleifera) is an ethnobotanical plant with lots of therapeutic potential, but there is a dearth of information on the bioactive properties of the seed alkaloid extracts. Method This study examined the modulatory effects of various concentrations of an alkaloid extract from the seeds of Horseradish Tree (Moringa oleifera) on the survival rate of flies exposed to paraquat, as well as certain biochemical and molecular markers related to Parkinson’s disease in the heads of the flies. Result The findings showed that the survival rate of the treated flies was significantly (p
ISSN:1552-5260
1552-5279
DOI:10.1002/alz.088477